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Mutation:
PPP1R12C E506D
Summary
Isoform:
Position:
506
Ref:
E
Mutation:
D
PTM impact:
distal
PTM affected:
2
Kinases:
CDK2
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 499S
Affected site:
Position: 499
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 505R | PPCLENSSPPSRI[P/R]PE | 6 |
distal
|
| 505S | PPCLENSSPPSRI[P/S]PE | 6 |
distal
|
| 494Y | PP[C/Y]CLENSSPPSRIPE | 5 |
distal
|
| 493L | P[P/L]PCLENSSPPSRIPE | 6 |
distal
|
| 505L | PPCLENSSPPSRI[P/L]PE | 6 |
distal
|
| 505A | PPCLENSSPPSRI[P/A]PE | 6 |
distal
|
PTM Site: 509S
Affected site:
Position: 509
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 514D | SRIPEPESPAKP[N/D]NVP | 5 |
distal
|
| 511V | SRIPEPESP[A/V]AKPNVP | 2 |
proximal
|
| 506D | SRIP[E/D]EPESPAKPNVP | 3 |
distal
|
| 505R | SRI[P/R]PEPESPAKPNVP | 4 |
distal
|
| 505S | SRI[P/S]PEPESPAKPNVP | 4 |
distal
|
| 505L | SRI[P/L]PEPESPAKPNVP | 4 |
distal
|
| 505A | SRI[P/A]PEPESPAKPNVP | 4 |
distal
|
| 507L | SRIPE[P/L]PESPAKPNVP | 2 |
proximal
|
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