PML A407S

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Mutation:

Summary

Isoform:

NM_033246

Position:

407

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

MAPK7, MAPK7

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

Liver-HCC

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 400K

Affected site:

Position: 400

Residue: K

Type: ubiquitination, sumoylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
403N	GKDAAVSKKA[S/N]SPEAA	3	distal

PTM Site: 401K

Affected site:

Position: 401

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
403N	KDAAVSKKA[S/N]SPEAAS	2	proximal
407S	KDAAVSKKASPEA[A/S]AS	6	distal

PTM Site: 403S

Affected site:

Position: 403

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
403N	AAVSKKA[S/N]SPEAASTP	0	direct
407S	AAVSKKASPEA[A/S]ASTP	4	distal

PTM Site: 408S

Affected site:

Position: 408

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
403N	KA[S/N]SPEAASTPRDPID	5	distal
413L	KASPEAASTPRD[P/L]PID	5	distal
410S	KASPEAAST[P/S]PRDPID	2	proximal
407S	KASPEA[A/S]ASTPRDPID	1	proximal

PTM Site: 409T

Affected site:

Position: 409

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
403N	A[S/N]SPEAASTPRDPIDV	6	distal
413L	ASPEAASTPRD[P/L]PIDV	4	distal
410S	ASPEAAST[P/S]PRDPIDV	1	network-rewiring
407S	ASPEA[A/S]ASTPRDPIDV	2	proximal

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