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Mutation:
PTPN13 R497I
Summary
Isoform:
Position:
497
Ref:
R
Mutation:
I
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
LIHC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 499S
Affected site:
Position: 499
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKACA (probability p=0.967)
Site: 499S (phosphorylation)
Position in motif: -2
There are 4 other predicted
losses:
- AURKA (p=0.963)
- AKT1 (p=0.948)
- PRKCD (p=0.936)
- ROCK1 (p=0.884)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 496V | AKMA[L/V]LRQSRLSLYPG | 3 |
distal
|
| 500P | AKMALRQS[R/P]RLSLYPG | 1 |
network-rewiring
|
| 497I | AKMAL[R/I]RQSRLSLYPG | 2 |
network-rewiring
|
PTM Site: 502S
Affected site:
Position: 502
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKACA (probability p=0.967)
Site: 499S (phosphorylation)
Position in motif: -2
There are 4 other predicted
losses:
- AURKA (p=0.963)
- AKT1 (p=0.948)
- PRKCD (p=0.936)
- ROCK1 (p=0.884)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 496V | A[L/V]LRQSRLSLYPGDTI | 6 |
distal
|
| 500P | ALRQS[R/P]RLSLYPGDTI | 2 |
network-rewiring
|
| 497I | AL[R/I]RQSRLSLYPGDTI | 5 |
network-rewiring
|
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