PTPN13 R500P

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Mutation:

Summary

Isoform:

NM_080683

Position:

500

Ref:

Mutation:

PTM impact:

network-rewiring

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.2309]

Minor Allele Frequency: (1000 Genomes)

[0.059904200000000005]

PTM Site: 499S

Affected site:

Position: 499

Residue: S

Type: phosphorylation

Best gain of PTM site:

MAPK3 (probability p=0.933)

Site: 499S (phosphorylation)

Position in motif: 1

There are 5 other predicted gains:

MAPK14 (p=0.928)
CDK1 (p=0.918)
MAPK1 (p=0.913)
CDK2 (p=0.866)
GSK3B (p=0.865)

Best loss of PTM site:

AURKA (probability p=0.991)

Site: 502S (phosphorylation)

Position in motif: -2

There are 3 other predicted losses:

PRKACA (p=0.967)
AURKB (p=0.937)
PRKCD (p=0.918)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
496V	AKMA[L/V]LRQSRLSLYPG	3	distal
500P	AKMALRQS[R/P]RLSLYPG	1	network-rewiring
497I	AKMAL[R/I]RQSRLSLYPG	2	network-rewiring

PTM Site: 502S

Affected site:

Position: 502

Residue: S

Type: phosphorylation

Best gain of PTM site:

MAPK3 (probability p=0.933)

Site: 499S (phosphorylation)

Position in motif: 1

There are 5 other predicted gains:

MAPK14 (p=0.928)
CDK1 (p=0.918)
MAPK1 (p=0.913)
CDK2 (p=0.866)
GSK3B (p=0.865)

Best loss of PTM site:

AURKA (probability p=0.991)

Site: 502S (phosphorylation)

Position in motif: -2

There are 3 other predicted losses:

PRKACA (p=0.967)
AURKB (p=0.937)
PRKCD (p=0.918)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
496V	A[L/V]LRQSRLSLYPGDTI	6	distal
500P	ALRQS[R/P]RLSLYPGDTI	2	network-rewiring
497I	AL[R/I]RQSRLSLYPGDTI	5	network-rewiring

If you have any questions or feedback about this mutation: