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Mutation:
EIF4G1 G733E
Summary
Isoform:
Position:
733
Ref:
G
Mutation:
E
PTM impact:
proximal
PTM affected:
2
Kinases:
PAK2
Clinical Information
Cancer types: (TCGA MC3)
LGG
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 731S
Affected site:
Position: 731
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 726V | RD[I/V]IARRRSLGNIKFI | 5 |
distal
|
| 729W | RDIAR[R/W]RRSLGNIKFI | 2 |
network-rewiring
|
| 733E | RDIARRRSL[G/E]GNIKFI | 2 |
proximal
|
| 730C | RDIARR[R/C]RSLGNIKFI | 1 |
proximal
|
PTM Site: 736K
Affected site:
Position: 736
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 741F | RRSLGNIKFIGE[L/F]LFK | 5 |
distal
|
| 733E | RRSL[G/E]GNIKFIGELFK | 3 |
distal
|
| 730C | R[R/C]RSLGNIKFIGELFK | 6 |
distal
|
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