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Mutation:
EGFR S229C
Summary
Isoform:
Position:
229
Ref:
S
Mutation:
C
PTM impact:
direct
PTM affected:
3
Kinases:
AKT1,
AKT2
Clinical Information
Cancer types: (TCGA MC3)
GBM, LUSC, HNSC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 222R
Affected site:
Position: 222
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 221R | CAQQCS[G/R]GRCRGKSPS | 1 |
proximal
|
| 222H | CAQQCSG[R/H]RCRGKSPS | 0 |
direct
|
| 224C | CAQQCSGRC[R/C]RGKSPS | 2 |
proximal
|
| 224H | CAQQCSGRC[R/H]RGKSPS | 2 |
proximal
|
| 222C | CAQQCSG[R/C]RCRGKSPS | 0 |
direct
|
| 223Y | CAQQCSGR[C/Y]CRGKSPS | 1 |
proximal
|
PTM Site: 224R
Affected site:
Position: 224
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 221R | QQCS[G/R]GRCRGKSPSDC | 3 |
distal
|
| 222H | QQCSG[R/H]RCRGKSPSDC | 2 |
proximal
|
| 224C | QQCSGRC[R/C]RGKSPSDC | 0 |
direct
|
| 224H | QQCSGRC[R/H]RGKSPSDC | 0 |
direct
|
| 222C | QQCSG[R/C]RCRGKSPSDC | 2 |
proximal
|
| 229C | QQCSGRCRGKSP[S/C]SDC | 5 |
distal
|
| 223Y | QQCSGR[C/Y]CRGKSPSDC | 1 |
proximal
|
PTM Site: 229S
Affected site:
Position: 229
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 224C | RC[R/C]RGKSPSDCCHNQC | 5 |
network-rewiring
|
| 224H | RC[R/H]RGKSPSDCCHNQC | 5 |
network-rewiring
|
| 229C | RCRGKSP[S/C]SDCCHNQC | 0 |
direct
|
| 223Y | R[C/Y]CRGKSPSDCCHNQC | 6 |
distal
|
| 234S | RCRGKSPSDCCH[N/S]NQC | 5 |
distal
|
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