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MTOR (NM_004958) - mechanistic target of rapamycin kinase

Serine/threonine-Protein Kinase Mtor

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of MTOR protein.
MTOR: serine/threonine-protein kinase mTOR
Description:

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: U88966.1, AB209995.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361445.9/ ENSP00000354558.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

Strand
-
Chromosome
1
Protein
2549 residues
All mutations
326
PTM sites
89
CDS
11,167,541 - 11,319,466
Transcription
11,166,587 - 11,322,608
13.34% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 2475
UniProt
Ensembl