MTOR (NM_004958) - mechanistic target of rapamycin

Serine/threonine-Protein Kinase Mtor

Mutations Visualisation

Protein summary

This is preferred isoform of MTOR protein.
MTOR: serine/threonine-protein kinase mTOR
Description:

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: AB209995.1, U88966.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
1
Protein
2549 residues
All mutations
300
PTM sites
53
CDS
11,167,541 - 11,319,466
Transcription
11,166,587 - 11,322,608
13.34% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 2475
Uniprot
Ensembl