You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

DYRK2 (NM_006482) - dual specificity tyrosine phosphorylation regulated kinase 2

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 Isoform 2

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of DYRK2 protein. View all 2 isoforms
DYRK2: dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
Description:

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
12
Protein
601 residues
All mutations
81
PTM sites
14
CDS
68,042,913 - 68,052,493
Transcription
68,042,511 - 68,056,444
37.27% of sequence is predicted to be disordered

Usage summary

Network

drag the background to move whole network
scroll to zoom in and out

PTM site

double click to focus on site's sub-network (or hide it)

Kinases group

double click to show/hide all kinases within the group.

Kinase, PTM site or protein

hover to see a tooltip with additional information
click to stick the tooltip
drag a node to move it and stick in a chosen place
shift + click to free a node which was stuck earlier

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 8445
UniProt
Ensembl