DYRK2 (NM_006482) - dual specificity tyrosine phosphorylation regulated kinase 2

Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 Isoform 2

Mutations Visualisation

Protein summary

This is preferred isoform of DYRK2 protein. View all 2 isoforms
DYRK2: dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
Description:

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].

Strand
+
Chromosome
12
Protein
601 residues
All mutations
77
PTM sites
11
CDS
68,042,913 - 68,052,493
Transcription
68,042,511 - 68,056,444
37.27% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 8445
Uniprot
Ensembl