RFC5 (NM_007370) - replication factor C subunit 5
Replication Factor C Subunit 5 Isoform 1
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Protein
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Protein summary
This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
- Strand
- +
- Chromosome
- 12
- Protein
- 340 residues
- All mutations
- 42
- PTM sites
- 17
- CDS
- 118,454,632 - 118,469,083
- Transcription
- 118,454,505 - 118,470,042
Usage summary
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Kinase, PTM site or protein
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