RFC5 (NM_007370) - replication factor C subunit 5

Replication Factor C Subunit 5 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of RFC5 protein. View all 4 isoforms
RFC5: replication factor C subunit 5 isoform 1
Description:

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

Strand
+
Chromosome
12
Protein
340 residues
All mutations
41
PTM sites
12
CDS
118,454,632 - 118,469,083
Transcription
118,454,505 - 118,470,042
5.29% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5985
Uniprot
Ensembl