PRKAA1 (NM_006251) - protein kinase AMP-activated catalytic subunit alpha 1
5'-Amp-Activated Protein Kinase Catalytic Subunit Alpha-1 Isoform 1
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Protein
Kinases
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PTM Interaction Network Visualisation
Protein summary
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
- Strand
- -
- Chromosome
- 5
- Protein
- 559 residues
- All mutations
- 64
- PTM sites
- 51
- CDS
- 40,762,879 - 40,798,291
- Transcription
- 40,759,480 - 40,798,297
Usage summary
Network
PTM site
Kinases group
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Kinase, PTM site or protein
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