PRKAA1 (NM_006251) - protein kinase AMP-activated catalytic subunit alpha 1

5'-Amp-Activated Protein Kinase Catalytic Subunit Alpha-1 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of PRKAA1 protein. View all 2 isoforms
PRKAA1: 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
Description:

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
5
Protein
559 residues
All mutations
63
PTM sites
39
CDS
40,762,879 - 40,798,291
Transcription
40,759,480 - 40,798,297
23.26% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5562
Uniprot
Ensembl