DAXX (NM_001350) - death domain associated protein

Death Domain-Associated Protein 6 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of DAXX protein. View all 4 isoforms
DAXX: death domain-associated protein 6 isoform a
Description:

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].

Strand
-
Chromosome
6
Protein
740 residues
All mutations
120
PTM sites
56
CDS
33,286,519 - 33,289,702
Transcription
33,286,334 - 33,290,793
62.3% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 1616
Uniprot
Ensembl