MDM4 (NM_002393) - MDM4, p53 regulator

Protein Mdm4 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of MDM4 protein. View all 7 isoforms
MDM4: protein Mdm4 isoform 1
Description:

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].

Strand
+
Chromosome
1
Protein
490 residues
All mutations
55
PTM sites
11
CDS
204,494,646 - 204,518,810
Transcription
204,485,506 - 204,527,248
62.45% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 4194
Uniprot
Ensembl