TP63 (NM_003722) - tumor protein p63

Tumor Protein 63 Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of TP63 protein. View all 6 isoforms
TP63: tumor protein 63 isoform 1
Description:

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].

Strand
+
Chromosome
3
Protein
680 residues
All mutations
171
PTM sites
17
CDS
189,349,304 - 189,612,291
Transcription
189,349,215 - 189,615,068
51.03% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 8626
Uniprot
Ensembl