TP73 (NM_005427) - tumor protein p73

Tumor Protein P73 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of TP73 protein. View all 13 isoforms
TP73: tumor protein p73 isoform a
Description:

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].

Strand
+
Chromosome
1
Protein
636 residues
All mutations
106
PTM sites
14
CDS
3,598,929 - 3,649,643
Transcription
3,569,128 - 3,652,765
56.13% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 7161
Uniprot
Ensembl