TOPBP1 (NM_007027) - topoisomerase (DNA) II binding protein 1

Dna Topoisomerase 2-Binding Protein 1

Mutations Visualisation

Protein summary

This is preferred isoform of TOPBP1 protein.
TOPBP1: DNA topoisomerase 2-binding protein 1
Description:

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: BC151237.1, SRR1660803.23079.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

Strand
-
Chromosome
3
Protein
1522 residues
All mutations
208
PTM sites
40
CDS
133,320,093 - 133,379,971
Transcription
133,319,448 - 133,380,737
42.84% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 11073
Uniprot
Ensembl