RAD17 (NM_133339) - RAD17 checkpoint clamp loader component

Cell Cycle Checkpoint Protein Rad17 Isoform 2

Mutations Visualisation

Protein summary

This is preferred isoform of RAD17 protein. View all 9 isoforms
RAD17: cell cycle checkpoint protein RAD17 isoform 2
Description:

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].

Strand
+
Chromosome
5
Protein
681 residues
All mutations
106
PTM sites
11
CDS
68,667,342 - 68,710,119
Transcription
68,667,280 - 68,710,628
29.81% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & Uniprot.
RefSeq
Entrez
gene: 5884
Uniprot
Ensembl