The results shown here are in whole or part based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/.
(as requested on cancergenome.nih.gov/publications/publicationguidelines)
This portal uses PhosphositePlus data which is not for commercial use; please see Terms and Conditions on following page: Terms of Use and License.
Publications of databases providing essential data for ActiveDriverDB:
- Dinkel, H. et al. Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic acids research 39, D261-267, doi:10.1093/nar/gkq1104 (2011).
- Keshava Prasad, T. S. et al. Human Protein Reference Database--2009 update. Nucleic acids research 37, D767-772, doi:10.1093/nar/gkn892 (2009).
- Cancer Genome Atlas Research, N. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nature genetics 45, 1113-1120, doi:10.1038/ng.2764 (2013).
- Genomes Project, C. et al. A global reference for human genetic variation. Nature 526, 68-74, doi:10.1038/nature15393 (2015).
- Tennessen, J. A. et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69, doi:10.1126/science.1219240 (2012).
- Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 42, D980-985, doi:10.1093/nar/gkt1113 (2014).
We used following resources to provide external references (protein mappings):
- The UniProt Consortium, UniProt: the universal protein knowledgebase Nucleic Acids Res. 45: D158-D169 (2017)
- HUMAN_9606_idmapping.dat.gz mappings file, accessed June 14 2017.
- The NCBI handbook [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2002 Oct. Chapter 18, The Reference Sequence (RefSeq) Project. Available from http://www.ncbi.nlm.nih.gov/books/NBK21091
- LRG_RefSeqGene mappings file, accessed June 14 2017.
Pathways lists are based on a gmt file retrieved from g:Profiler resource:
- J. Reimand, T. Arak, P. Adler, L. Kolberg, S. Reisberg, H. Peterson, J. Vilo: g:Profiler -- a web server for functional interpretation of gene lists (2016 update) Nucleic Acids Research 2016; doi: 10.1093/nar/gkw199
Protein description summaries and full protein names (as on RefSeq pages) were retrieved using UCSC Table browser:
- Karolchik D, Hinrichs AS, Furey TS, Roskin KM, Sugnet CW, Haussler D, Kent WJ. The UCSC Table Browser data retrieval tool. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D493-6.
DrugBank (CC-BY-NC/4.0 licensed) data are used for drug kinase interaction visualisations:
- Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.