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The primary publication of ActiveDriverDB:


ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins

Michal Krassowski, Marta Paczkowska, Kim Cullion, Tina Huang, Irakli Dzneladze, B. F. Francis Ouellette, Joseph T. Yamada, Amelie Fradet-Turcotte, Jüri Reimand

Nucleic Acids Research, gkx973,



The earlier preprint of the paper is available in bioRxiv.


Earlier publications on systematic analyses of PTM-associated mutations in cancer, genetic disease variation and population genomics: 

  • Narayan, S., Bader, G. D. & Reimand, J. Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer. Genome Med 8, 55, doi:10.1186/s13073-016-0311-2 (2016).
  • Reimand, J., Wagih, O. & Bader, G. D. Evolutionary constraint and disease associations of post-translational modification sites in human genomes. PLoS Genet 11, e1004919, doi:10.1371/journal.pgen.1004919 (2015).
  • Wagih, O., Reimand, J. & Bader, G. D. MIMP: predicting the impact of mutations on kinase-substrate phosphorylation. Nat Methods 12, 531-533, doi:10.1038/nmeth.3396 (2015).
  • Reimand, J. & Bader, G. D. Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Molecular systems biology 9, 637, doi:10.1038/msb.2012.68 (2013).