TP53 Y163C

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Mutation:

Isoform:

NM_000546

Position:

163

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

LUSC, OV, LUAD, BRCA, HNSC, COAD, LGG, ESCA

Lung-SCC, Lung-AdenoCA, Liver-HCC, Breast-AdenoCa, Ovary-AdenoCA

Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome

no data

no data

Position: 164

Residue: K

Type: ubiquitination, acetylation

proximal

Mutation	In sequence	Distance	Impact
170M	VRAMAIYKQSQHM[T/M]TE	6	distal
170R	VRAMAIYKQSQHM[T/R]TE	6	distal
170A	VRAMAIYKQSQHM[T/A]TE	6	distal
169I	VRAMAIYKQSQH[M/I]MTE	5	distal
169R	VRAMAIYKQSQH[M/R]MTE	5	distal
169V	VRAMAIYKQSQH[M/V]MTE	5	distal
168R	VRAMAIYKQSQ[H/R]HMTE	4	distal
167R	VRAMAIYKQS[Q/R]QHMTE	3	distal
167P	VRAMAIYKQS[Q/P]QHMTE	3	distal
166L	VRAMAIYKQ[S/L]SQHMTE	2	proximal
165K	VRAMAIYK[Q/K]QSQHMTE	1	proximal
164N	VRAMAIY[K/N]KQSQHMTE	0	direct
164E	VRAMAIY[K/E]KQSQHMTE	0	direct
163C	VRAMAI[Y/C]YKQSQHMTE	1	proximal
163D	VRAMAI[Y/D]YKQSQHMTE	1	proximal
163H	VRAMAI[Y/H]YKQSQHMTE	1	proximal
163N	VRAMAI[Y/N]YKQSQHMTE	1	proximal
162F	VRAMA[I/F]IYKQSQHMTE	2	proximal
161D	VRAM[A/D]AIYKQSQHMTE	3	distal
161T	VRAM[A/T]AIYKQSQHMTE	3	distal
159V	VR[A/V]AMAIYKQSQHMTE	5	distal
159P	VR[A/P]AMAIYKQSQHMTE	5	distal
158L	V[R/L]RAMAIYKQSQHMTE	6	distal
158P	V[R/P]RAMAIYKQSQHMTE	6	distal
158H	V[R/H]RAMAIYKQSQHMTE	6	distal
158C	V[R/C]RAMAIYKQSQHMTE	6	distal
158G	V[R/G]RAMAIYKQSQHMTE	6	distal
168L	VRAMAIYKQSQ[H/L]HMTE	4	distal
161V	VRAM[A/V]AIYKQSQHMTE	3	distal
161S	VRAM[A/S]AIYKQSQHMTE	3	distal
160I	VRA[M/I]MAIYKQSQHMTE	4	distal
162N	VRAMA[I/N]IYKQSQHMTE	2	proximal
168P	VRAMAIYKQSQ[H/P]HMTE	4	distal
161P	VRAM[A/P]AIYKQSQHMTE	3	distal
158S	V[R/S]RAMAIYKQSQHMTE	6	distal

dbSNP:

rs148924904

If you have any questions or feedback about this mutation: