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Mutation:
TP53 R158C
Summary
Isoform:
Position:
158
Ref:
R
Mutation:
C
PTM impact:
distal
PTM affected:
2
Kinases:
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 155T
Affected site:
Position: 155
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 155S | DSTPPPG[T/S]TRVRAMAI | 0 |
direct
|
| 155N | DSTPPPG[T/N]TRVRAMAI | 0 |
direct
|
| 155A | DSTPPPG[T/A]TRVRAMAI | 0 |
direct
|
| 155I | DSTPPPG[T/I]TRVRAMAI | 0 |
direct
|
| 155P | DSTPPPG[T/P]TRVRAMAI | 0 |
direct
|
PTM Site: 164K
Affected site:
Position: 164
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 164N | VRAMAIY[K/N]KQSQHMTE | 0 |
direct
|
| 164E | VRAMAIY[K/E]KQSQHMTE | 0 |
direct
|
| 165K | VRAMAIYK[Q/K]QSQHMTE | 1 |
proximal
|
| 163C | VRAMAI[Y/C]YKQSQHMTE | 1 |
proximal
|
| 163D | VRAMAI[Y/D]YKQSQHMTE | 1 |
proximal
|
External references
dbSNP:
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