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Mutation:

TP53 R158H

Summary

Isoform:
NM_000546
Position:
158
Ref:
R
Mutation:
H
PTM impact:
distal
PTM affected:
2
Kinases:
CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

GBM, LUSC, STAD, COAD, HNSC, SARC, PRAD, LGG, BLCA, ESCA, LIHC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 155T

Affected site:

Position: 155
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
161D DSTPPPGTRVRAM[A/D]AI 6
distal
161T DSTPPPGTRVRAM[A/T]AI 6
distal
159V DSTPPPGTRVR[A/V]AMAI 4
distal
159P DSTPPPGTRVR[A/P]AMAI 4
distal
158L DSTPPPGTRV[R/L]RAMAI 3
distal
158P DSTPPPGTRV[R/P]RAMAI 3
distal
158H DSTPPPGTRV[R/H]RAMAI 3
distal
158C DSTPPPGTRV[R/C]RAMAI 3
distal
158G DSTPPPGTRV[R/G]RAMAI 3
distal
157G DSTPPPGTR[V/G]VRAMAI 2
proximal
157A DSTPPPGTR[V/A]VRAMAI 2
proximal
157D DSTPPPGTR[V/D]VRAMAI 2
proximal
157F DSTPPPGTR[V/F]VRAMAI 2
proximal
157I DSTPPPGTR[V/I]VRAMAI 2
proximal
156P DSTPPPGT[R/P]RVRAMAI 1
network-rewiring
156H DSTPPPGT[R/H]RVRAMAI 1
proximal
156C DSTPPPGT[R/C]RVRAMAI 1
proximal
155S DSTPPPG[T/S]TRVRAMAI 0
direct
155N DSTPPPG[T/N]TRVRAMAI 0
direct
155A DSTPPPG[T/A]TRVRAMAI 0
direct
154V DSTPPP[G/V]GTRVRAMAI 1
proximal
154D DSTPPP[G/D]GTRVRAMAI 1
proximal
154R DSTPPP[G/R]GTRVRAMAI 1
proximal
154S DSTPPP[G/S]GTRVRAMAI 1
proximal
153L DSTPP[P/L]PGTRVRAMAI 2
proximal
153S DSTPP[P/S]PGTRVRAMAI 2
proximal
152L DSTP[P/L]PPGTRVRAMAI 3
distal
152R DSTP[P/R]PPGTRVRAMAI 3
network-rewiring
152S DSTP[P/S]PPGTRVRAMAI 3
distal
151R DST[P/R]PPPGTRVRAMAI 4
distal
151H DST[P/H]PPPGTRVRAMAI 4
distal
151S DST[P/S]PPPGTRVRAMAI 4
distal
151A DST[P/A]PPPGTRVRAMAI 4
distal
151T DST[P/T]PPPGTRVRAMAI 4
distal
149F D[S/F]STPPPGTRVRAMAI 6
distal
155I DSTPPPG[T/I]TRVRAMAI 0
direct
155P DSTPPPG[T/P]TRVRAMAI 0
direct
156G DSTPPPGT[R/G]RVRAMAI 1
proximal
157L DSTPPPGTR[V/L]VRAMAI 2
proximal
161V DSTPPPGTRVRAM[A/V]AI 6
distal
152Q DSTP[P/Q]PPGTRVRAMAI 3
distal
161S DSTPPPGTRVRAM[A/S]AI 6
distal
160I DSTPPPGTRVRA[M/I]MAI 5
distal
161P DSTPPPGTRVRAM[A/P]AI 6
distal
158S DSTPPPGTRV[R/S]RAMAI 3
network-rewiring

PTM Site: 164K

Affected site:

Position: 164
Residue: K
Type: ubiquitination, acetylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
170M VRAMAIYKQSQHM[T/M]TE 6
distal
170R VRAMAIYKQSQHM[T/R]TE 6
distal
170A VRAMAIYKQSQHM[T/A]TE 6
distal
169I VRAMAIYKQSQH[M/I]MTE 5
distal
169R VRAMAIYKQSQH[M/R]MTE 5
distal
169V VRAMAIYKQSQH[M/V]MTE 5
distal
168R VRAMAIYKQSQ[H/R]HMTE 4
distal
167R VRAMAIYKQS[Q/R]QHMTE 3
distal
167P VRAMAIYKQS[Q/P]QHMTE 3
distal
166L VRAMAIYKQ[S/L]SQHMTE 2
proximal
165K VRAMAIYK[Q/K]QSQHMTE 1
proximal
164N VRAMAIY[K/N]KQSQHMTE 0
direct
164E VRAMAIY[K/E]KQSQHMTE 0
direct
163C VRAMAI[Y/C]YKQSQHMTE 1
proximal
163D VRAMAI[Y/D]YKQSQHMTE 1
proximal
163H VRAMAI[Y/H]YKQSQHMTE 1
proximal
163N VRAMAI[Y/N]YKQSQHMTE 1
proximal
162F VRAMA[I/F]IYKQSQHMTE 2
proximal
161D VRAM[A/D]AIYKQSQHMTE 3
distal
161T VRAM[A/T]AIYKQSQHMTE 3
distal
159V VR[A/V]AMAIYKQSQHMTE 5
distal
159P VR[A/P]AMAIYKQSQHMTE 5
distal
158L V[R/L]RAMAIYKQSQHMTE 6
distal
158P V[R/P]RAMAIYKQSQHMTE 6
distal
158H V[R/H]RAMAIYKQSQHMTE 6
distal
158C V[R/C]RAMAIYKQSQHMTE 6
distal
158G V[R/G]RAMAIYKQSQHMTE 6
distal
168L VRAMAIYKQSQ[H/L]HMTE 4
distal
161V VRAM[A/V]AIYKQSQHMTE 3
distal
161S VRAM[A/S]AIYKQSQHMTE 3
distal
160I VRA[M/I]MAIYKQSQHMTE 4
distal
162N VRAMA[I/N]IYKQSQHMTE 2
proximal
168P VRAMAIYKQSQ[H/P]HMTE 4
distal
161P VRAM[A/P]AIYKQSQHMTE 3
distal
158S V[R/S]RAMAIYKQSQHMTE 6
distal

External references

dbSNP:
rs587782144

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