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Mutation:
TP53 G302E
Summary
Isoform:
Position:
302
Ref:
G
Mutation:
E
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
LRRK2,
EP300
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 304T
Affected site:
Position: 304
Residue: T
Type: phosphorylation
Only gain of PTM site:
PLK1 (probability p=0.893)
Site: 304T (phosphorylation)
Position in motif: -2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 310K | HELPPGSTKRALP[N/K]NN | 6 |
distal
|
| 310D | HELPPGSTKRALP[N/D]NN | 6 |
distal
|
| 309S | HELPPGSTKRAL[P/S]PNN | 5 |
distal
|
| 307V | HELPPGSTKR[A/V]ALPNN | 3 |
distal
|
| 307G | HELPPGSTKR[A/G]ALPNN | 3 |
distal
|
| 306Q | HELPPGSTK[R/Q]RALPNN | 2 |
network-rewiring
|
| 304A | HELPPGS[T/A]TKRALPNN | 0 |
direct
|
| 303N | HELPPG[S/N]STKRALPNN | 1 |
proximal
|
| 303G | HELPPG[S/G]STKRALPNN | 1 |
proximal
|
| 302E | HELPP[G/E]GSTKRALPNN | 2 |
network-rewiring
|
| 302R | HELPP[G/R]GSTKRALPNN | 2 |
network-rewiring
|
| 301L | HELP[P/L]PGSTKRALPNN | 3 |
distal
|
| 298G | H[E/G]ELPPGSTKRALPNN | 6 |
distal
|
| 298K | H[E/K]ELPPGSTKRALPNN | 6 |
distal
|
PTM Site: 305K
Affected site:
Position: 305
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 311S | ELPPGSTKRALPN[N/S]NT | 6 |
distal
|
| 311T | ELPPGSTKRALPN[N/T]NT | 6 |
distal
|
| 311H | ELPPGSTKRALPN[N/H]NT | 6 |
distal
|
| 310K | ELPPGSTKRALP[N/K]NNT | 5 |
distal
|
| 310D | ELPPGSTKRALP[N/D]NNT | 5 |
distal
|
| 309S | ELPPGSTKRAL[P/S]PNNT | 4 |
distal
|
| 307V | ELPPGSTKR[A/V]ALPNNT | 2 |
proximal
|
| 307G | ELPPGSTKR[A/G]ALPNNT | 2 |
proximal
|
| 306Q | ELPPGSTK[R/Q]RALPNNT | 1 |
proximal
|
| 304A | ELPPGS[T/A]TKRALPNNT | 1 |
proximal
|
| 303N | ELPPG[S/N]STKRALPNNT | 2 |
proximal
|
| 303G | ELPPG[S/G]STKRALPNNT | 2 |
proximal
|
| 302E | ELPP[G/E]GSTKRALPNNT | 3 |
distal
|
| 302R | ELPP[G/R]GSTKRALPNNT | 3 |
distal
|
| 301L | ELP[P/L]PGSTKRALPNNT | 4 |
distal
|
External references
dbSNP:
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