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Mutation:
TP53 E298G
Summary
Isoform:
Position:
298
Ref:
E
Mutation:
G
PTM impact:
distal
PTM affected:
4
Kinases:
EP300,
LRRK2,
EP300
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 291K
Affected site:
Position: 291
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
PTM Site: 292K
Affected site:
Position: 292
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 298G | EEENLRKKGEPHH[E/G]EL | 6 |
distal
|
| 298K | EEENLRKKGEPHH[E/K]EL | 6 |
distal
|
| 297Q | EEENLRKKGEPH[H/Q]HEL | 5 |
distal
|
| 297R | EEENLRKKGEPH[H/R]HEL | 5 |
distal
|
| 296Y | EEENLRKKGEP[H/Y]HHEL | 4 |
distal
|
| 295L | EEENLRKKGE[P/L]PHHEL | 3 |
distal
|
| 295S | EEENLRKKGE[P/S]PHHEL | 3 |
distal
|
| 293W | EEENLRKK[G/W]GEPHHEL | 1 |
proximal
|
| 293R | EEENLRKK[G/R]GEPHHEL | 1 |
proximal
|
| 292I | EEENLRK[K/I]KGEPHHEL | 0 |
direct
|
| 292R | EEENLRK[K/R]KGEPHHEL | 0 |
direct
|
| 291N | EEENLR[K/N]KKGEPHHEL | 1 |
proximal
|
| 291E | EEENLR[K/E]KKGEPHHEL | 1 |
proximal
|
| 290L | EEENL[R/L]RKKGEPHHEL | 2 |
proximal
|
| 290P | EEENL[R/P]RKKGEPHHEL | 2 |
proximal
|
| 290H | EEENL[R/H]RKKGEPHHEL | 2 |
proximal
|
| 290C | EEENL[R/C]RKKGEPHHEL | 2 |
proximal
|
| 290G | EEENL[R/G]RKKGEPHHEL | 2 |
proximal
|
| 289F | EEEN[L/F]LRKKGEPHHEL | 3 |
distal
|
| 287D | EE[E/D]ENLRKKGEPHHEL | 5 |
distal
|
| 287K | EE[E/K]ENLRKKGEPHHEL | 5 |
distal
|
| 286V | E[E/V]EENLRKKGEPHHEL | 6 |
distal
|
| 286G | E[E/G]EENLRKKGEPHHEL | 6 |
distal
|
| 286A | E[E/A]EENLRKKGEPHHEL | 6 |
distal
|
| 286Q | E[E/Q]EENLRKKGEPHHEL | 6 |
distal
|
| 286K | E[E/K]EENLRKKGEPHHEL | 6 |
distal
|
| 287Q | EE[E/Q]ENLRKKGEPHHEL | 5 |
distal
|
PTM Site: 304T
Affected site:
Position: 304
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 310K | HELPPGSTKRALP[N/K]NN | 6 |
distal
|
| 310D | HELPPGSTKRALP[N/D]NN | 6 |
distal
|
| 309S | HELPPGSTKRAL[P/S]PNN | 5 |
distal
|
| 307V | HELPPGSTKR[A/V]ALPNN | 3 |
distal
|
| 307G | HELPPGSTKR[A/G]ALPNN | 3 |
distal
|
| 306Q | HELPPGSTK[R/Q]RALPNN | 2 |
network-rewiring
|
| 304A | HELPPGS[T/A]TKRALPNN | 0 |
direct
|
| 303N | HELPPG[S/N]STKRALPNN | 1 |
proximal
|
| 303G | HELPPG[S/G]STKRALPNN | 1 |
proximal
|
| 302E | HELPP[G/E]GSTKRALPNN | 2 |
network-rewiring
|
| 302R | HELPP[G/R]GSTKRALPNN | 2 |
network-rewiring
|
| 301L | HELP[P/L]PGSTKRALPNN | 3 |
distal
|
| 298G | H[E/G]ELPPGSTKRALPNN | 6 |
distal
|
| 298K | H[E/K]ELPPGSTKRALPNN | 6 |
distal
|
PTM Site: 305K
Affected site:
Position: 305
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 311S | ELPPGSTKRALPN[N/S]NT | 6 |
distal
|
| 311T | ELPPGSTKRALPN[N/T]NT | 6 |
distal
|
| 311H | ELPPGSTKRALPN[N/H]NT | 6 |
distal
|
| 310K | ELPPGSTKRALP[N/K]NNT | 5 |
distal
|
| 310D | ELPPGSTKRALP[N/D]NNT | 5 |
distal
|
| 309S | ELPPGSTKRAL[P/S]PNNT | 4 |
distal
|
| 307V | ELPPGSTKR[A/V]ALPNNT | 2 |
proximal
|
| 307G | ELPPGSTKR[A/G]ALPNNT | 2 |
proximal
|
| 306Q | ELPPGSTK[R/Q]RALPNNT | 1 |
proximal
|
| 304A | ELPPGS[T/A]TKRALPNNT | 1 |
proximal
|
| 303N | ELPPG[S/N]STKRALPNNT | 2 |
proximal
|
| 303G | ELPPG[S/G]STKRALPNNT | 2 |
proximal
|
| 302E | ELPP[G/E]GSTKRALPNNT | 3 |
distal
|
| 302R | ELPP[G/R]GSTKRALPNNT | 3 |
distal
|
| 301L | ELP[P/L]PGSTKRALPNNT | 4 |
distal
|
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