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Mutation:
TP53 E298K
Summary
Isoform:
Position:
298
Ref:
E
Mutation:
K
PTM impact:
distal
PTM affected:
4
Kinases:
EP300,
LRRK2,
EP300
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 291K
Affected site:
Position: 291
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 291N | TEEENLR[K/N]KKGEPHHE | 0 |
direct
|
| 291E | TEEENLR[K/E]KKGEPHHE | 0 |
direct
|
| 292I | TEEENLRK[K/I]KGEPHHE | 1 |
proximal
|
| 292R | TEEENLRK[K/R]KGEPHHE | 1 |
proximal
|
| 290L | TEEENL[R/L]RKKGEPHHE | 1 |
proximal
|
PTM Site: 292K
Affected site:
Position: 292
Residue: K
Type: acetylation, ubiquitination
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 292I | EEENLRK[K/I]KGEPHHEL | 0 |
direct
|
| 292R | EEENLRK[K/R]KGEPHHEL | 0 |
direct
|
| 293W | EEENLRKK[G/W]GEPHHEL | 1 |
proximal
|
| 293R | EEENLRKK[G/R]GEPHHEL | 1 |
proximal
|
| 291N | EEENLR[K/N]KKGEPHHEL | 1 |
proximal
|
PTM Site: 304T
Affected site:
Position: 304
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 304A | HELPPGS[T/A]TKRALPNN | 0 |
direct
|
| 303N | HELPPG[S/N]STKRALPNN | 1 |
proximal
|
| 303G | HELPPG[S/G]STKRALPNN | 1 |
proximal
|
| 306Q | HELPPGSTK[R/Q]RALPNN | 2 |
network-rewiring
|
| 302E | HELPP[G/E]GSTKRALPNN | 2 |
network-rewiring
|
PTM Site: 305K
Affected site:
Position: 305
Residue: K
Type: acetylation, ubiquitination
Impact:
distalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 306Q | ELPPGSTK[R/Q]RALPNNT | 1 |
proximal
|
| 304A | ELPPGS[T/A]TKRALPNNT | 1 |
proximal
|
| 307V | ELPPGSTKR[A/V]ALPNNT | 2 |
proximal
|
| 307G | ELPPGSTKR[A/G]ALPNNT | 2 |
proximal
|
| 303N | ELPPG[S/N]STKRALPNNT | 2 |
proximal
|
External references
dbSNP:
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