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Mutation:
TP53 P316S
Summary
Isoform:
Position:
316
Ref:
P
Mutation:
S
PTM impact:
network-rewiring
PTM affected:
7
Kinases:
CDK1,
CDK5,
AURKA,
CDK2,
NEK2,
CDK9,
AURORA A,
KAT2B
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 312T
Affected site:
Position: 312
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318L | KRALPNNTSSSPQ[P/L]PK | 6 |
distal
|
| 317H | KRALPNNTSSSP[Q/H]QPK | 5 |
distal
|
| 317L | KRALPNNTSSSP[Q/L]QPK | 5 |
distal
|
| 317R | KRALPNNTSSSP[Q/R]QPK | 5 |
distal
|
| 317K | KRALPNNTSSSP[Q/K]QPK | 5 |
distal
|
| 316L | KRALPNNTSSS[P/L]PQPK | 4 |
distal
|
| 316S | KRALPNNTSSS[P/S]PQPK | 4 |
distal
|
| 316T | KRALPNNTSSS[P/T]PQPK | 4 |
distal
|
| 315C | KRALPNNTSS[S/C]SPQPK | 3 |
distal
|
| 315T | KRALPNNTSS[S/T]SPQPK | 3 |
distal
|
| 314F | KRALPNNTS[S/F]SSPQPK | 2 |
proximal
|
| 314C | KRALPNNTS[S/C]SSPQPK | 2 |
proximal
|
| 312S | KRALPNN[T/S]TSSSPQPK | 0 |
direct
|
| 311S | KRALPN[N/S]NTSSSPQPK | 1 |
proximal
|
| 311T | KRALPN[N/T]NTSSSPQPK | 1 |
proximal
|
| 311H | KRALPN[N/H]NTSSSPQPK | 1 |
proximal
|
| 310K | KRALP[N/K]NNTSSSPQPK | 2 |
proximal
|
| 310D | KRALP[N/D]NNTSSSPQPK | 2 |
proximal
|
| 309S | KRAL[P/S]PNNTSSSPQPK | 3 |
network-rewiring
|
| 307V | KR[A/V]ALPNNTSSSPQPK | 5 |
distal
|
| 307G | KR[A/G]ALPNNTSSSPQPK | 5 |
distal
|
| 306Q | K[R/Q]RALPNNTSSSPQPK | 6 |
distal
|
PTM Site: 313S
Affected site:
Position: 313
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318L | RALPNNTSSSPQ[P/L]PKK | 5 |
distal
|
| 317H | RALPNNTSSSP[Q/H]QPKK | 4 |
distal
|
| 317L | RALPNNTSSSP[Q/L]QPKK | 4 |
distal
|
| 317R | RALPNNTSSSP[Q/R]QPKK | 4 |
distal
|
| 317K | RALPNNTSSSP[Q/K]QPKK | 4 |
distal
|
| 316L | RALPNNTSSS[P/L]PQPKK | 3 |
distal
|
| 316S | RALPNNTSSS[P/S]PQPKK | 3 |
distal
|
| 316T | RALPNNTSSS[P/T]PQPKK | 3 |
distal
|
| 315C | RALPNNTSS[S/C]SPQPKK | 2 |
proximal
|
| 315T | RALPNNTSS[S/T]SPQPKK | 2 |
proximal
|
| 314F | RALPNNTS[S/F]SSPQPKK | 1 |
network-rewiring
|
| 314C | RALPNNTS[S/C]SSPQPKK | 1 |
proximal
|
| 312S | RALPNN[T/S]TSSSPQPKK | 1 |
proximal
|
| 311S | RALPN[N/S]NTSSSPQPKK | 2 |
proximal
|
| 311T | RALPN[N/T]NTSSSPQPKK | 2 |
proximal
|
| 311H | RALPN[N/H]NTSSSPQPKK | 2 |
proximal
|
| 310K | RALP[N/K]NNTSSSPQPKK | 3 |
network-rewiring
|
| 310D | RALP[N/D]NNTSSSPQPKK | 3 |
distal
|
| 309S | RAL[P/S]PNNTSSSPQPKK | 4 |
distal
|
| 307V | R[A/V]ALPNNTSSSPQPKK | 6 |
distal
|
| 307G | R[A/G]ALPNNTSSSPQPKK | 6 |
distal
|
| 319N | RALPNNTSSSPQP[K/N]KK | 6 |
distal
|
PTM Site: 314S
Affected site:
Position: 314
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318L | ALPNNTSSSPQ[P/L]PKKK | 4 |
distal
|
| 317H | ALPNNTSSSP[Q/H]QPKKK | 3 |
distal
|
| 317L | ALPNNTSSSP[Q/L]QPKKK | 3 |
distal
|
| 317R | ALPNNTSSSP[Q/R]QPKKK | 3 |
distal
|
| 317K | ALPNNTSSSP[Q/K]QPKKK | 3 |
distal
|
| 316L | ALPNNTSSS[P/L]PQPKKK | 2 |
proximal
|
| 316S | ALPNNTSSS[P/S]PQPKKK | 2 |
proximal
|
| 316T | ALPNNTSSS[P/T]PQPKKK | 2 |
proximal
|
| 315C | ALPNNTSS[S/C]SPQPKKK | 1 |
proximal
|
| 315T | ALPNNTSS[S/T]SPQPKKK | 1 |
proximal
|
| 314F | ALPNNTS[S/F]SSPQPKKK | 0 |
direct
|
| 314C | ALPNNTS[S/C]SSPQPKKK | 0 |
direct
|
| 312S | ALPNN[T/S]TSSSPQPKKK | 2 |
proximal
|
| 311S | ALPN[N/S]NTSSSPQPKKK | 3 |
distal
|
| 311T | ALPN[N/T]NTSSSPQPKKK | 3 |
distal
|
| 311H | ALPN[N/H]NTSSSPQPKKK | 3 |
distal
|
| 310K | ALP[N/K]NNTSSSPQPKKK | 4 |
distal
|
| 310D | ALP[N/D]NNTSSSPQPKKK | 4 |
distal
|
| 309S | AL[P/S]PNNTSSSPQPKKK | 5 |
distal
|
| 320E | ALPNNTSSSPQPK[K/E]KK | 6 |
distal
|
| 319N | ALPNNTSSSPQP[K/N]KKK | 5 |
distal
|
PTM Site: 315S
Affected site:
Position: 315
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.956)
Site: 315S (phosphorylation)
Position in motif: 1
There are 8 other predicted
losses:
- MAPK3 (p=0.954)
- CDK5 (p=0.952)
- MAPK14 (p=0.91)
- CDK1 (p=0.907)
- MTOR (p=0.896)
- MAPK9 (p=0.876)
- GSK3B (p=0.864)
- CDK4 (p=0.851)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318L | LPNNTSSSPQ[P/L]PKKKP | 3 |
distal
|
| 317H | LPNNTSSSP[Q/H]QPKKKP | 2 |
proximal
|
| 317L | LPNNTSSSP[Q/L]QPKKKP | 2 |
proximal
|
| 317R | LPNNTSSSP[Q/R]QPKKKP | 2 |
network-rewiring
|
| 317K | LPNNTSSSP[Q/K]QPKKKP | 2 |
network-rewiring
|
| 316L | LPNNTSSS[P/L]PQPKKKP | 1 |
network-rewiring
|
| 316S | LPNNTSSS[P/S]PQPKKKP | 1 |
network-rewiring
|
| 316T | LPNNTSSS[P/T]PQPKKKP | 1 |
network-rewiring
|
| 315C | LPNNTSS[S/C]SPQPKKKP | 0 |
direct
|
| 315T | LPNNTSS[S/T]SPQPKKKP | 0 |
direct
|
| 314F | LPNNTS[S/F]SSPQPKKKP | 1 |
proximal
|
| 314C | LPNNTS[S/C]SSPQPKKKP | 1 |
proximal
|
| 312S | LPNN[T/S]TSSSPQPKKKP | 3 |
distal
|
| 311S | LPN[N/S]NTSSSPQPKKKP | 4 |
distal
|
| 311T | LPN[N/T]NTSSSPQPKKKP | 4 |
distal
|
| 311H | LPN[N/H]NTSSSPQPKKKP | 4 |
distal
|
| 310K | LP[N/K]NNTSSSPQPKKKP | 5 |
distal
|
| 310D | LP[N/D]NNTSSSPQPKKKP | 5 |
distal
|
| 309S | L[P/S]PNNTSSSPQPKKKP | 6 |
distal
|
| 320E | LPNNTSSSPQPK[K/E]KKP | 5 |
distal
|
| 319N | LPNNTSSSPQP[K/N]KKKP | 4 |
distal
|
PTM Site: 319K
Affected site:
Position: 319
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | TSSSPQPKKKPLD[G/V]GE | 6 |
distal
|
| 325E | TSSSPQPKKKPLD[G/E]GE | 6 |
distal
|
| 325R | TSSSPQPKKKPLD[G/R]GE | 6 |
distal
|
| 324Y | TSSSPQPKKKPL[D/Y]DGE | 5 |
distal
|
| 324H | TSSSPQPKKKPL[D/H]DGE | 5 |
distal
|
| 323P | TSSSPQPKKKP[L/P]LDGE | 4 |
distal
|
| 322S | TSSSPQPKKK[P/S]PLDGE | 3 |
distal
|
| 322T | TSSSPQPKKK[P/T]PLDGE | 3 |
distal
|
| 318L | TSSSPQ[P/L]PKKKPLDGE | 1 |
proximal
|
| 317H | TSSSP[Q/H]QPKKKPLDGE | 2 |
proximal
|
| 317L | TSSSP[Q/L]QPKKKPLDGE | 2 |
proximal
|
| 317R | TSSSP[Q/R]QPKKKPLDGE | 2 |
proximal
|
| 317K | TSSSP[Q/K]QPKKKPLDGE | 2 |
proximal
|
| 316L | TSSS[P/L]PQPKKKPLDGE | 3 |
distal
|
| 316S | TSSS[P/S]PQPKKKPLDGE | 3 |
distal
|
| 316T | TSSS[P/T]PQPKKKPLDGE | 3 |
distal
|
| 315C | TSS[S/C]SPQPKKKPLDGE | 4 |
distal
|
| 315T | TSS[S/T]SPQPKKKPLDGE | 4 |
distal
|
| 314F | TS[S/F]SSPQPKKKPLDGE | 5 |
distal
|
| 314C | TS[S/C]SSPQPKKKPLDGE | 5 |
distal
|
| 320E | TSSSPQPK[K/E]KKPLDGE | 1 |
proximal
|
| 319N | TSSSPQP[K/N]KKKPLDGE | 0 |
direct
|
PTM Site: 320K
Affected site:
Position: 320
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | SSSPQPKKKPLD[G/V]GEY | 5 |
distal
|
| 325E | SSSPQPKKKPLD[G/E]GEY | 5 |
distal
|
| 325R | SSSPQPKKKPLD[G/R]GEY | 5 |
distal
|
| 324Y | SSSPQPKKKPL[D/Y]DGEY | 4 |
distal
|
| 324H | SSSPQPKKKPL[D/H]DGEY | 4 |
distal
|
| 323P | SSSPQPKKKP[L/P]LDGEY | 3 |
distal
|
| 322S | SSSPQPKKK[P/S]PLDGEY | 2 |
proximal
|
| 322T | SSSPQPKKK[P/T]PLDGEY | 2 |
proximal
|
| 318L | SSSPQ[P/L]PKKKPLDGEY | 2 |
proximal
|
| 317H | SSSP[Q/H]QPKKKPLDGEY | 3 |
distal
|
| 317L | SSSP[Q/L]QPKKKPLDGEY | 3 |
distal
|
| 317R | SSSP[Q/R]QPKKKPLDGEY | 3 |
distal
|
| 317K | SSSP[Q/K]QPKKKPLDGEY | 3 |
distal
|
| 316L | SSS[P/L]PQPKKKPLDGEY | 4 |
distal
|
| 316S | SSS[P/S]PQPKKKPLDGEY | 4 |
distal
|
| 316T | SSS[P/T]PQPKKKPLDGEY | 4 |
distal
|
| 315C | SS[S/C]SPQPKKKPLDGEY | 5 |
distal
|
| 315T | SS[S/T]SPQPKKKPLDGEY | 5 |
distal
|
| 314F | S[S/F]SSPQPKKKPLDGEY | 6 |
distal
|
| 314C | S[S/C]SSPQPKKKPLDGEY | 6 |
distal
|
| 320E | SSSPQPK[K/E]KKPLDGEY | 0 |
direct
|
| 319N | SSSPQP[K/N]KKKPLDGEY | 1 |
proximal
|
PTM Site: 321K
Affected site:
Position: 321
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | SSPQPKKKPLD[G/V]GEYF | 4 |
distal
|
| 325E | SSPQPKKKPLD[G/E]GEYF | 4 |
distal
|
| 325R | SSPQPKKKPLD[G/R]GEYF | 4 |
distal
|
| 324Y | SSPQPKKKPL[D/Y]DGEYF | 3 |
distal
|
| 324H | SSPQPKKKPL[D/H]DGEYF | 3 |
distal
|
| 323P | SSPQPKKKP[L/P]LDGEYF | 2 |
proximal
|
| 322S | SSPQPKKK[P/S]PLDGEYF | 1 |
proximal
|
| 322T | SSPQPKKK[P/T]PLDGEYF | 1 |
proximal
|
| 318L | SSPQ[P/L]PKKKPLDGEYF | 3 |
distal
|
| 317H | SSP[Q/H]QPKKKPLDGEYF | 4 |
distal
|
| 317L | SSP[Q/L]QPKKKPLDGEYF | 4 |
distal
|
| 317R | SSP[Q/R]QPKKKPLDGEYF | 4 |
distal
|
| 317K | SSP[Q/K]QPKKKPLDGEYF | 4 |
distal
|
| 316L | SS[P/L]PQPKKKPLDGEYF | 5 |
distal
|
| 316S | SS[P/S]PQPKKKPLDGEYF | 5 |
distal
|
| 316T | SS[P/T]PQPKKKPLDGEYF | 5 |
distal
|
| 315C | S[S/C]SPQPKKKPLDGEYF | 6 |
distal
|
| 315T | S[S/T]SPQPKKKPLDGEYF | 6 |
distal
|
| 320E | SSPQPK[K/E]KKPLDGEYF | 1 |
proximal
|
| 319N | SSPQP[K/N]KKKPLDGEYF | 2 |
proximal
|
External references
dbSNP:
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