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Mutation:
TP53 P322T
Summary
Isoform:
Position:
322
Ref:
P
Mutation:
T
PTM impact:
proximal
PTM affected:
5
Kinases:
AURKA,
CDK9,
CDK1,
CDK5,
AURORA A,
CDK2,
NEK2,
KAT2B
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 315S
Affected site:
Position: 315
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318L | LPNNTSSSPQ[P/L]PKKKP | 3 |
distal
|
| 317H | LPNNTSSSP[Q/H]QPKKKP | 2 |
proximal
|
| 317L | LPNNTSSSP[Q/L]QPKKKP | 2 |
proximal
|
| 317R | LPNNTSSSP[Q/R]QPKKKP | 2 |
network-rewiring
|
| 317K | LPNNTSSSP[Q/K]QPKKKP | 2 |
network-rewiring
|
| 316L | LPNNTSSS[P/L]PQPKKKP | 1 |
network-rewiring
|
| 316S | LPNNTSSS[P/S]PQPKKKP | 1 |
network-rewiring
|
| 316T | LPNNTSSS[P/T]PQPKKKP | 1 |
network-rewiring
|
| 315C | LPNNTSS[S/C]SPQPKKKP | 0 |
direct
|
| 315T | LPNNTSS[S/T]SPQPKKKP | 0 |
direct
|
| 314F | LPNNTS[S/F]SSPQPKKKP | 1 |
proximal
|
| 314C | LPNNTS[S/C]SSPQPKKKP | 1 |
proximal
|
| 312S | LPNN[T/S]TSSSPQPKKKP | 3 |
distal
|
| 311S | LPN[N/S]NTSSSPQPKKKP | 4 |
distal
|
| 311T | LPN[N/T]NTSSSPQPKKKP | 4 |
distal
|
| 311H | LPN[N/H]NTSSSPQPKKKP | 4 |
distal
|
| 310K | LP[N/K]NNTSSSPQPKKKP | 5 |
distal
|
| 310D | LP[N/D]NNTSSSPQPKKKP | 5 |
distal
|
| 309S | L[P/S]PNNTSSSPQPKKKP | 6 |
distal
|
| 320E | LPNNTSSSPQPK[K/E]KKP | 5 |
distal
|
| 319N | LPNNTSSSPQP[K/N]KKKP | 4 |
distal
|
PTM Site: 319K
Affected site:
Position: 319
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | TSSSPQPKKKPLD[G/V]GE | 6 |
distal
|
| 325E | TSSSPQPKKKPLD[G/E]GE | 6 |
distal
|
| 325R | TSSSPQPKKKPLD[G/R]GE | 6 |
distal
|
| 324Y | TSSSPQPKKKPL[D/Y]DGE | 5 |
distal
|
| 324H | TSSSPQPKKKPL[D/H]DGE | 5 |
distal
|
| 323P | TSSSPQPKKKP[L/P]LDGE | 4 |
distal
|
| 322S | TSSSPQPKKK[P/S]PLDGE | 3 |
distal
|
| 322T | TSSSPQPKKK[P/T]PLDGE | 3 |
distal
|
| 318L | TSSSPQ[P/L]PKKKPLDGE | 1 |
proximal
|
| 317H | TSSSP[Q/H]QPKKKPLDGE | 2 |
proximal
|
| 317L | TSSSP[Q/L]QPKKKPLDGE | 2 |
proximal
|
| 317R | TSSSP[Q/R]QPKKKPLDGE | 2 |
proximal
|
| 317K | TSSSP[Q/K]QPKKKPLDGE | 2 |
proximal
|
| 316L | TSSS[P/L]PQPKKKPLDGE | 3 |
distal
|
| 316S | TSSS[P/S]PQPKKKPLDGE | 3 |
distal
|
| 316T | TSSS[P/T]PQPKKKPLDGE | 3 |
distal
|
| 315C | TSS[S/C]SPQPKKKPLDGE | 4 |
distal
|
| 315T | TSS[S/T]SPQPKKKPLDGE | 4 |
distal
|
| 314F | TS[S/F]SSPQPKKKPLDGE | 5 |
distal
|
| 314C | TS[S/C]SSPQPKKKPLDGE | 5 |
distal
|
| 320E | TSSSPQPK[K/E]KKPLDGE | 1 |
proximal
|
| 319N | TSSSPQP[K/N]KKKPLDGE | 0 |
direct
|
PTM Site: 320K
Affected site:
Position: 320
Residue: K
Type: ubiquitination, acetylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | SSSPQPKKKPLD[G/V]GEY | 5 |
distal
|
| 325E | SSSPQPKKKPLD[G/E]GEY | 5 |
distal
|
| 325R | SSSPQPKKKPLD[G/R]GEY | 5 |
distal
|
| 324Y | SSSPQPKKKPL[D/Y]DGEY | 4 |
distal
|
| 324H | SSSPQPKKKPL[D/H]DGEY | 4 |
distal
|
| 323P | SSSPQPKKKP[L/P]LDGEY | 3 |
distal
|
| 322S | SSSPQPKKK[P/S]PLDGEY | 2 |
proximal
|
| 322T | SSSPQPKKK[P/T]PLDGEY | 2 |
proximal
|
| 318L | SSSPQ[P/L]PKKKPLDGEY | 2 |
proximal
|
| 317H | SSSP[Q/H]QPKKKPLDGEY | 3 |
distal
|
| 317L | SSSP[Q/L]QPKKKPLDGEY | 3 |
distal
|
| 317R | SSSP[Q/R]QPKKKPLDGEY | 3 |
distal
|
| 317K | SSSP[Q/K]QPKKKPLDGEY | 3 |
distal
|
| 316L | SSS[P/L]PQPKKKPLDGEY | 4 |
distal
|
| 316S | SSS[P/S]PQPKKKPLDGEY | 4 |
distal
|
| 316T | SSS[P/T]PQPKKKPLDGEY | 4 |
distal
|
| 315C | SS[S/C]SPQPKKKPLDGEY | 5 |
distal
|
| 315T | SS[S/T]SPQPKKKPLDGEY | 5 |
distal
|
| 314F | S[S/F]SSPQPKKKPLDGEY | 6 |
distal
|
| 314C | S[S/C]SSPQPKKKPLDGEY | 6 |
distal
|
| 320E | SSSPQPK[K/E]KKPLDGEY | 0 |
direct
|
| 319N | SSSPQP[K/N]KKKPLDGEY | 1 |
proximal
|
PTM Site: 321K
Affected site:
Position: 321
Residue: K
Type: ubiquitination, acetylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 325V | SSPQPKKKPLD[G/V]GEYF | 4 |
distal
|
| 325E | SSPQPKKKPLD[G/E]GEYF | 4 |
distal
|
| 325R | SSPQPKKKPLD[G/R]GEYF | 4 |
distal
|
| 324Y | SSPQPKKKPL[D/Y]DGEYF | 3 |
distal
|
| 324H | SSPQPKKKPL[D/H]DGEYF | 3 |
distal
|
| 323P | SSPQPKKKP[L/P]LDGEYF | 2 |
proximal
|
| 322S | SSPQPKKK[P/S]PLDGEYF | 1 |
proximal
|
| 322T | SSPQPKKK[P/T]PLDGEYF | 1 |
proximal
|
| 318L | SSPQ[P/L]PKKKPLDGEYF | 3 |
distal
|
| 317H | SSP[Q/H]QPKKKPLDGEYF | 4 |
distal
|
| 317L | SSP[Q/L]QPKKKPLDGEYF | 4 |
distal
|
| 317R | SSP[Q/R]QPKKKPLDGEYF | 4 |
distal
|
| 317K | SSP[Q/K]QPKKKPLDGEYF | 4 |
distal
|
| 316L | SS[P/L]PQPKKKPLDGEYF | 5 |
distal
|
| 316S | SS[P/S]PQPKKKPLDGEYF | 5 |
distal
|
| 316T | SS[P/T]PQPKKKPLDGEYF | 5 |
distal
|
| 315C | S[S/C]SPQPKKKPLDGEYF | 6 |
distal
|
| 315T | S[S/T]SPQPKKKPLDGEYF | 6 |
distal
|
| 320E | SSPQPK[K/E]KKPLDGEYF | 1 |
proximal
|
| 319N | SSPQP[K/N]KKKPLDGEYF | 2 |
proximal
|
PTM Site: 327Y
Affected site:
Position: 327
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 333H | KKPLDGEYFTLQI[R/H]RG | 6 |
distal
|
| 333C | KKPLDGEYFTLQI[R/C]RG | 6 |
distal
|
| 332M | KKPLDGEYFTLQ[I/M]IRG | 5 |
distal
|
| 331R | KKPLDGEYFTL[Q/R]QIRG | 4 |
distal
|
| 331K | KKPLDGEYFTL[Q/K]QIRG | 4 |
distal
|
| 330P | KKPLDGEYFT[L/P]LQIRG | 3 |
distal
|
| 329I | KKPLDGEYF[T/I]TLQIRG | 2 |
proximal
|
| 329A | KKPLDGEYF[T/A]TLQIRG | 2 |
proximal
|
| 328S | KKPLDGEY[F/S]FTLQIRG | 1 |
proximal
|
| 325V | KKPLD[G/V]GEYFTLQIRG | 2 |
proximal
|
| 325E | KKPLD[G/E]GEYFTLQIRG | 2 |
proximal
|
| 325R | KKPLD[G/R]GEYFTLQIRG | 2 |
proximal
|
| 324Y | KKPL[D/Y]DGEYFTLQIRG | 3 |
network-rewiring
|
| 324H | KKPL[D/H]DGEYFTLQIRG | 3 |
network-rewiring
|
| 323P | KKP[L/P]LDGEYFTLQIRG | 4 |
distal
|
| 322S | KK[P/S]PLDGEYFTLQIRG | 5 |
distal
|
| 322T | KK[P/T]PLDGEYFTLQIRG | 5 |
distal
|
| 331H | KKPLDGEYFTL[Q/H]QIRG | 4 |
distal
|
| 332F | KKPLDGEYFTLQ[I/F]IRG | 5 |
distal
|
External references
dbSNP:
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