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Mutation:
TP53 Q317K
Summary
Isoform:
Position:
317
Ref:
Q
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
7
Kinases:
CDK5,
CDK9,
AURORA A,
CDK1,
CDK2,
NEK2,
AURKA,
KAT2B
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 312T
Affected site:
Position: 312
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 312S | KRALPNN[T/S]TSSSPQPK | 0 |
direct
|
| 311S | KRALPN[N/S]NTSSSPQPK | 1 |
proximal
|
| 311T | KRALPN[N/T]NTSSSPQPK | 1 |
proximal
|
| 311H | KRALPN[N/H]NTSSSPQPK | 1 |
proximal
|
| 314F | KRALPNNTS[S/F]SSPQPK | 2 |
proximal
|
PTM Site: 313S
Affected site:
Position: 313
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 314F | RALPNNTS[S/F]SSPQPKK | 1 |
network-rewiring
|
| 314C | RALPNNTS[S/C]SSPQPKK | 1 |
proximal
|
| 312S | RALPNN[T/S]TSSSPQPKK | 1 |
proximal
|
| 315C | RALPNNTSS[S/C]SPQPKK | 2 |
proximal
|
| 315T | RALPNNTSS[S/T]SPQPKK | 2 |
proximal
|
PTM Site: 314S
Affected site:
Position: 314
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 314F | ALPNNTS[S/F]SSPQPKKK | 0 |
direct
|
| 314C | ALPNNTS[S/C]SSPQPKKK | 0 |
direct
|
| 315C | ALPNNTSS[S/C]SPQPKKK | 1 |
proximal
|
| 315T | ALPNNTSS[S/T]SPQPKKK | 1 |
proximal
|
| 316L | ALPNNTSSS[P/L]PQPKKK | 2 |
proximal
|
PTM Site: 315S
Affected site:
Position: 315
Residue: S
Type: phosphorylation
Only gain of PTM site:
PRKCA (probability p=0.944)
Site: 315S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 315C | LPNNTSS[S/C]SPQPKKKP | 0 |
direct
|
| 315T | LPNNTSS[S/T]SPQPKKKP | 0 |
direct
|
| 316L | LPNNTSSS[P/L]PQPKKKP | 1 |
network-rewiring
|
| 316S | LPNNTSSS[P/S]PQPKKKP | 1 |
network-rewiring
|
| 316T | LPNNTSSS[P/T]PQPKKKP | 1 |
network-rewiring
|
PTM Site: 319K
Affected site:
Position: 319
Residue: K
Type: ubiquitination, acetylation
Impact:
proximalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 319N | TSSSPQP[K/N]KKKPLDGE | 0 |
direct
|
| 318L | TSSSPQ[P/L]PKKKPLDGE | 1 |
proximal
|
| 320E | TSSSPQPK[K/E]KKPLDGE | 1 |
proximal
|
| 317H | TSSSP[Q/H]QPKKKPLDGE | 2 |
proximal
|
| 317L | TSSSP[Q/L]QPKKKPLDGE | 2 |
proximal
|
PTM Site: 320K
Affected site:
Position: 320
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 320E | SSSPQPK[K/E]KKPLDGEY | 0 |
direct
|
| 319N | SSSPQP[K/N]KKKPLDGEY | 1 |
proximal
|
| 322S | SSSPQPKKK[P/S]PLDGEY | 2 |
proximal
|
| 322T | SSSPQPKKK[P/T]PLDGEY | 2 |
proximal
|
| 318L | SSSPQ[P/L]PKKKPLDGEY | 2 |
proximal
|
PTM Site: 321K
Affected site:
Position: 321
Residue: K
Type: ubiquitination, acetylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 322S | SSPQPKKK[P/S]PLDGEYF | 1 |
proximal
|
| 322T | SSPQPKKK[P/T]PLDGEYF | 1 |
proximal
|
| 320E | SSPQPK[K/E]KKPLDGEYF | 1 |
proximal
|
| 323P | SSPQPKKKP[L/P]LDGEYF | 2 |
proximal
|
| 319N | SSPQP[K/N]KKKPLDGEYF | 2 |
proximal
|
External references
dbSNP:
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