After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.

We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.

For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Summary

Isoform:
Position:
151
Ref:
S
Mutation:
G
PTM impact:
direct
PTM affected:
2
Kinases:
PRKCA, PRKACA, KIS

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0154]

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 151S

Affected site:

Position: 151
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
151G FKLGGRD[S/G]SRSGSPMA 0
direct
147E FKL[G/E]GGRDSRSGSPMA 4
distal
147R FKL[G/R]GGRDSRSGSPMA 4
distal
157T FKLGGRDSRSGSP[M/T]MA 6
distal
145M F[K/M]KLGGRDSRSGSPMA 6
distal
152P FKLGGRDS[R/P]RSGSPMA 1
network-rewiring
152C FKLGGRDS[R/C]RSGSPMA 1
proximal

PTM Site: 155S

Affected site:

Position: 155
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
151G GRD[S/G]SRSGSPMARR-- 4
distal
157T GRDSRSGSP[M/T]MARR-- 2
proximal
152P GRDS[R/P]RSGSPMARR-- 3
network-rewiring
152C GRDS[R/C]RSGSPMARR-- 3
network-rewiring

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