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Mutation:
MBP R152P
Summary
Isoform:
Position:
152
Ref:
R
Mutation:
P
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
PRKCA,
PRKACA,
KIS
Clinical Information
Cancer types: (TCGA MC3)
LUSC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 151S
Affected site:
Position: 151
Residue: S
Type: phosphorylation
Best gain of PTM site:
MAPK1 (probability p=0.939)
Site: 151S (phosphorylation)
Position in motif: 1
There are 6 other predicted
gains:
- MAPK3 (p=0.919)
- MAPK14 (p=0.905)
- CDK1 (p=0.901)
- CDK6 (p=0.9)
- CDK2 (p=0.894)
- CDK3 (p=0.865)
Best loss of PTM site:
AKT1 (probability p=0.974)
Site: 155S (phosphorylation)
Position in motif: -3
There are 5 other predicted
losses:
- PRKACA (p=0.949)
- MAPKAPK2 (p=0.884)
- PRKAA1 (p=0.88)
- SGK1 (p=0.878)
- PRKD1 (p=0.852)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 151G | FKLGGRD[S/G]SRSGSPMA | 0 |
direct
|
| 147E | FKL[G/E]GGRDSRSGSPMA | 4 |
distal
|
| 147R | FKL[G/R]GGRDSRSGSPMA | 4 |
distal
|
| 157T | FKLGGRDSRSGSP[M/T]MA | 6 |
distal
|
| 145M | F[K/M]KLGGRDSRSGSPMA | 6 |
distal
|
| 152P | FKLGGRDS[R/P]RSGSPMA | 1 |
network-rewiring
|
| 152C | FKLGGRDS[R/C]RSGSPMA | 1 |
proximal
|
PTM Site: 155S
Affected site:
Position: 155
Residue: S
Type: phosphorylation
Best gain of PTM site:
MAPK1 (probability p=0.939)
Site: 151S (phosphorylation)
Position in motif: 1
There are 6 other predicted
gains:
- MAPK3 (p=0.919)
- MAPK14 (p=0.905)
- CDK1 (p=0.901)
- CDK6 (p=0.9)
- CDK2 (p=0.894)
- CDK3 (p=0.865)
Best loss of PTM site:
AKT1 (probability p=0.974)
Site: 155S (phosphorylation)
Position in motif: -3
There are 5 other predicted
losses:
- PRKACA (p=0.949)
- MAPKAPK2 (p=0.884)
- PRKAA1 (p=0.88)
- SGK1 (p=0.878)
- PRKD1 (p=0.852)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 151G | GRD[S/G]SRSGSPMARR-- | 4 |
distal
|
| 157T | GRDSRSGSP[M/T]MARR-- | 2 |
proximal
|
| 152P | GRDS[R/P]RSGSPMARR-- | 3 |
network-rewiring
|
| 152C | GRDS[R/C]RSGSPMARR-- | 3 |
network-rewiring
|
If you have any questions or feedback about this mutation:
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