MBP G147R

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Mutation:

Summary

Isoform:

NM_001025092

Position:

147

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

PRKCA, PRKACA, PRKCA

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 141S

Affected site:

Position: 141

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
147E	VDAQGTLSKIFKL[G/E]GG	6	distal
147R	VDAQGTLSKIFKL[G/R]GG	6	distal
142R	VDAQGTLS[K/R]KIFKLGG	1	proximal
145M	VDAQGTLSKIF[K/M]KLGG	4	distal
142E	VDAQGTLS[K/E]KIFKLGG	1	proximal
135N	V[D/N]DAQGTLSKIFKLGG	6	distal
143F	VDAQGTLSK[I/F]IFKLGG	2	proximal

PTM Site: 151S

Affected site:

Position: 151

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
151G	FKLGGRD[S/G]SRSGSPMA	0	direct
147E	FKL[G/E]GGRDSRSGSPMA	4	distal
147R	FKL[G/R]GGRDSRSGSPMA	4	distal
157T	FKLGGRDSRSGSP[M/T]MA	6	distal
145M	F[K/M]KLGGRDSRSGSPMA	6	distal
152P	FKLGGRDS[R/P]RSGSPMA	1	network-rewiring
152C	FKLGGRDS[R/C]RSGSPMA	1	proximal

If you have any questions or feedback about this mutation: