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Summary

Isoform:
Position:
130
Ref:
R
Mutation:
H
PTM impact:
network-rewiring
PTM affected:
5
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

GBM

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 125S

Affected site:

Position: 125
Residue: S
Type: phosphorylation

Impact:

distal

PTM Site: 132S

Affected site:

Position: 132
Residue: S
Type: phosphorylation

Best loss of PTM site:

PRKACA (probability p=0.965)
Site: 132S (phosphorylation)
Position in motif: -2
There are 2 other predicted losses:
  • AKT1 (p=0.949)
  • AURKB (p=0.928)

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I SRSRSRRSY[R/I]RSSRSP 2
proximal
131Q SRSRSR[R/Q]RSYRSSRSP 1
proximal
131W SRSRSR[R/W]RSYRSSRSP 1
proximal
130H SRSRS[R/H]RRSYRSSRSP 2
network-rewiring
137K SRSRSRRSYRSS[R/K]RSP 5
distal
128K SRS[R/K]RSRRSYRSSRSP 4
distal
131P SRSRSR[R/P]RSYRSSRSP 1
proximal
128I SRS[R/I]RSRRSYRSSRSP 4
distal
129A SRSR[S/A]SRRSYRSSRSP 3
network-rewiring
137M SRSRSRRSYRSS[R/M]RSP 5
distal

PTM Site: 133Y

Affected site:

Position: 133
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSRSRRSY[R/I]RSSRSPR 1
proximal
131Q RSRSR[R/Q]RSYRSSRSPR 2
proximal
131W RSRSR[R/W]RSYRSSRSPR 2
proximal
130H RSRS[R/H]RRSYRSSRSPR 3
distal
137K RSRSRRSYRSS[R/K]RSPR 4
distal
128K RS[R/K]RSRRSYRSSRSPR 5
distal
131P RSRSR[R/P]RSYRSSRSPR 2
proximal
128I RS[R/I]RSRRSYRSSRSPR 5
distal
129A RSR[S/A]SRRSYRSSRSPR 4
distal
137M RSRSRRSYRSS[R/M]RSPR 4
distal

PTM Site: 135S

Affected site:

Position: 135
Residue: S
Type: phosphorylation

Best loss of PTM site:

PRKACA (probability p=0.965)
Site: 132S (phosphorylation)
Position in motif: -2
There are 2 other predicted losses:
  • AKT1 (p=0.949)
  • AURKB (p=0.928)

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSRRSY[R/I]RSSRSPRSS 1
proximal
131Q RSR[R/Q]RSYRSSRSPRSS 4
distal
131W RSR[R/W]RSYRSSRSPRSS 4
distal
130H RS[R/H]RRSYRSSRSPRSS 5
network-rewiring
137K RSRRSYRSS[R/K]RSPRSS 2
proximal
131P RSR[R/P]RSYRSSRSPRSS 4
distal
141L RSRRSYRSSRSPR[S/L]SS 6
distal
129A R[S/A]SRRSYRSSRSPRSS 6
distal
137M RSRRSYRSS[R/M]RSPRSS 2
network-rewiring

PTM Site: 136S

Affected site:

Position: 136
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I SRRSY[R/I]RSSRSPRSSS 2
network-rewiring
131Q SR[R/Q]RSYRSSRSPRSSS 5
network-rewiring
131W SR[R/W]RSYRSSRSPRSSS 5
network-rewiring
130H S[R/H]RRSYRSSRSPRSSS 6
distal
137K SRRSYRSS[R/K]RSPRSSS 1
proximal
131P SR[R/P]RSYRSSRSPRSSS 5
network-rewiring
141L SRRSYRSSRSPR[S/L]SSS 5
distal
137M SRRSYRSS[R/M]RSPRSSS 1
proximal

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