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Mutation:
BCLAF1 S141L
Summary
Clinical Information
Cancer types: (TCGA MC3)
SKCM
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 135S
Affected site:
Position: 135
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134I | RSRRSY[R/I]RSSRSPRSS | 1 |
proximal
|
| 131Q | RSR[R/Q]RSYRSSRSPRSS | 4 |
distal
|
| 131W | RSR[R/W]RSYRSSRSPRSS | 4 |
distal
|
| 130H | RS[R/H]RRSYRSSRSPRSS | 5 |
network-rewiring
|
| 137K | RSRRSYRSS[R/K]RSPRSS | 2 |
proximal
|
| 131P | RSR[R/P]RSYRSSRSPRSS | 4 |
distal
|
| 141L | RSRRSYRSSRSPR[S/L]SS | 6 |
distal
|
| 129A | R[S/A]SRRSYRSSRSPRSS | 6 |
distal
|
| 137M | RSRRSYRSS[R/M]RSPRSS | 2 |
network-rewiring
|
PTM Site: 136S
Affected site:
Position: 136
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134I | SRRSY[R/I]RSSRSPRSSS | 2 |
network-rewiring
|
| 131Q | SR[R/Q]RSYRSSRSPRSSS | 5 |
network-rewiring
|
| 131W | SR[R/W]RSYRSSRSPRSSS | 5 |
network-rewiring
|
| 130H | S[R/H]RRSYRSSRSPRSSS | 6 |
distal
|
| 137K | SRRSYRSS[R/K]RSPRSSS | 1 |
proximal
|
| 131P | SR[R/P]RSYRSSRSPRSSS | 5 |
network-rewiring
|
| 141L | SRRSYRSSRSPR[S/L]SSS | 5 |
distal
|
| 137M | SRRSYRSS[R/M]RSPRSSS | 1 |
proximal
|
PTM Site: 138S
Affected site:
Position: 138
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134I | RSY[R/I]RSSRSPRSSSSR | 4 |
distal
|
| 137K | RSYRSS[R/K]RSPRSSSSR | 1 |
proximal
|
| 141L | RSYRSSRSPR[S/L]SSSSR | 3 |
distal
|
| 137M | RSYRSS[R/M]RSPRSSSSR | 1 |
proximal
|
| 144A | RSYRSSRSPRSSS[S/A]SR | 6 |
distal
|
PTM Site: 141S
Affected site:
Position: 141
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145H | RSSRSPRSSSS[R/H]RSSS | 4 |
distal
|
| 145C | RSSRSPRSSSS[R/C]RSSS | 4 |
distal
|
| 147L | RSSRSPRSSSSRS[S/L]SS | 6 |
distal
|
| 137K | RSS[R/K]RSPRSSSSRSSS | 4 |
distal
|
| 141L | RSSRSPR[S/L]SSSSRSSS | 0 |
direct
|
| 137M | RSS[R/M]RSPRSSSSRSSS | 4 |
distal
|
| 144A | RSSRSPRSSS[S/A]SRSSS | 3 |
distal
|
PTM Site: 146S
Affected site:
Position: 146
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145H | PRSSSS[R/H]RSSSPYSKS | 1 |
proximal
|
| 145C | PRSSSS[R/C]RSSSPYSKS | 1 |
proximal
|
| 149T | PRSSSSRSSS[P/T]PYSKS | 3 |
distal
|
| 147L | PRSSSSRS[S/L]SSPYSKS | 1 |
network-rewiring
|
| 148Y | PRSSSSRSS[S/Y]SPYSKS | 2 |
proximal
|
| 150H | PRSSSSRSSSP[Y/H]YSKS | 4 |
distal
|
| 141L | PR[S/L]SSSSRSSSPYSKS | 5 |
distal
|
| 152R | PRSSSSRSSSPYS[K/R]KS | 6 |
distal
|
| 144A | PRSSS[S/A]SRSSSPYSKS | 2 |
proximal
|
| 149L | PRSSSSRSSS[P/L]PYSKS | 3 |
distal
|
PTM Site: 148S
Affected site:
Position: 148
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145H | SSSS[R/H]RSSSPYSKSPV | 3 |
network-rewiring
|
| 145C | SSSS[R/C]RSSSPYSKSPV | 3 |
network-rewiring
|
| 149T | SSSSRSSS[P/T]PYSKSPV | 1 |
network-rewiring
|
| 147L | SSSSRS[S/L]SSPYSKSPV | 1 |
proximal
|
| 148Y | SSSSRSS[S/Y]SPYSKSPV | 0 |
direct
|
| 150H | SSSSRSSSP[Y/H]YSKSPV | 2 |
proximal
|
| 152R | SSSSRSSSPYS[K/R]KSPV | 4 |
distal
|
| 144A | SSS[S/A]SRSSSPYSKSPV | 4 |
distal
|
| 149L | SSSSRSSS[P/L]PYSKSPV | 1 |
network-rewiring
|
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