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Summary

Isoform:
Position:
141
Ref:
S
Mutation:
L
PTM impact:
direct
PTM affected:
6
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

SKCM

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 135S

Affected site:

Position: 135
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSRRSY[R/I]RSSRSPRSS 1
proximal
131Q RSR[R/Q]RSYRSSRSPRSS 4
distal
131W RSR[R/W]RSYRSSRSPRSS 4
distal
130H RS[R/H]RRSYRSSRSPRSS 5
network-rewiring
137K RSRRSYRSS[R/K]RSPRSS 2
proximal
131P RSR[R/P]RSYRSSRSPRSS 4
distal
141L RSRRSYRSSRSPR[S/L]SS 6
distal
129A R[S/A]SRRSYRSSRSPRSS 6
distal
137M RSRRSYRSS[R/M]RSPRSS 2
network-rewiring

PTM Site: 136S

Affected site:

Position: 136
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I SRRSY[R/I]RSSRSPRSSS 2
network-rewiring
131Q SR[R/Q]RSYRSSRSPRSSS 5
network-rewiring
131W SR[R/W]RSYRSSRSPRSSS 5
network-rewiring
130H S[R/H]RRSYRSSRSPRSSS 6
distal
137K SRRSYRSS[R/K]RSPRSSS 1
proximal
131P SR[R/P]RSYRSSRSPRSSS 5
network-rewiring
141L SRRSYRSSRSPR[S/L]SSS 5
distal
137M SRRSYRSS[R/M]RSPRSSS 1
proximal

PTM Site: 138S

Affected site:

Position: 138
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSY[R/I]RSSRSPRSSSSR 4
distal
137K RSYRSS[R/K]RSPRSSSSR 1
proximal
141L RSYRSSRSPR[S/L]SSSSR 3
distal
137M RSYRSS[R/M]RSPRSSSSR 1
proximal
144A RSYRSSRSPRSSS[S/A]SR 6
distal

PTM Site: 141S

Affected site:

Position: 141
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H RSSRSPRSSSS[R/H]RSSS 4
distal
145C RSSRSPRSSSS[R/C]RSSS 4
distal
147L RSSRSPRSSSSRS[S/L]SS 6
distal
137K RSS[R/K]RSPRSSSSRSSS 4
distal
141L RSSRSPR[S/L]SSSSRSSS 0
direct
137M RSS[R/M]RSPRSSSSRSSS 4
distal
144A RSSRSPRSSS[S/A]SRSSS 3
distal

PTM Site: 146S

Affected site:

Position: 146
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H PRSSSS[R/H]RSSSPYSKS 1
proximal
145C PRSSSS[R/C]RSSSPYSKS 1
proximal
149T PRSSSSRSSS[P/T]PYSKS 3
distal
147L PRSSSSRS[S/L]SSPYSKS 1
network-rewiring
148Y PRSSSSRSS[S/Y]SPYSKS 2
proximal
150H PRSSSSRSSSP[Y/H]YSKS 4
distal
141L PR[S/L]SSSSRSSSPYSKS 5
distal
152R PRSSSSRSSSPYS[K/R]KS 6
distal
144A PRSSS[S/A]SRSSSPYSKS 2
proximal
149L PRSSSSRSSS[P/L]PYSKS 3
distal

PTM Site: 148S

Affected site:

Position: 148
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H SSSS[R/H]RSSSPYSKSPV 3
network-rewiring
145C SSSS[R/C]RSSSPYSKSPV 3
network-rewiring
149T SSSSRSSS[P/T]PYSKSPV 1
network-rewiring
147L SSSSRS[S/L]SSPYSKSPV 1
proximal
148Y SSSSRSS[S/Y]SPYSKSPV 0
direct
150H SSSSRSSSP[Y/H]YSKSPV 2
proximal
152R SSSSRSSSPYS[K/R]KSPV 4
distal
144A SSS[S/A]SRSSSPYSKSPV 4
distal
149L SSSSRSSS[P/L]PYSKSPV 1
network-rewiring

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