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Summary

Isoform:
Position:
156
Ref:
S
Mutation:
F
PTM impact:
direct
PTM affected:
6
Kinases:
SRC

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 150Y

Affected site:

Position: 150
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H SS[R/H]RSSSPYSKSPVSK 5
distal
145C SS[R/C]RSSSPYSKSPVSK 5
distal
156F SSRSSSPYSKSPV[S/F]SK 6
distal
149T SSRSSS[P/T]PYSKSPVSK 1
proximal
147L SSRS[S/L]SSPYSKSPVSK 3
distal
148Y SSRSS[S/Y]SPYSKSPVSK 2
proximal
150H SSRSSSP[Y/H]YSKSPVSK 0
direct
152R SSRSSSPYS[K/R]KSPVSK 2
proximal
144A S[S/A]SRSSSPYSKSPVSK 6
distal
149L SSRSSS[P/L]PYSKSPVSK 1
proximal

PTM Site: 151S

Affected site:

Position: 151
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H S[R/H]RSSSPYSKSPVSKR 6
distal
145C S[R/C]RSSSPYSKSPVSKR 6
distal
156F SRSSSPYSKSPV[S/F]SKR 5
distal
149T SRSSS[P/T]PYSKSPVSKR 2
proximal
147L SRS[S/L]SSPYSKSPVSKR 4
distal
148Y SRSS[S/Y]SPYSKSPVSKR 3
network-rewiring
150H SRSSSP[Y/H]YSKSPVSKR 1
proximal
152R SRSSSPYS[K/R]KSPVSKR 1
proximal
149L SRSSS[P/L]PYSKSPVSKR 2
proximal

PTM Site: 152K

Affected site:

Position: 152
Residue: K
Type: acetylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
156F RSSSPYSKSPV[S/F]SKRR 4
distal
149T RSSS[P/T]PYSKSPVSKRR 3
distal
147L RS[S/L]SSPYSKSPVSKRR 5
distal
148Y RSS[S/Y]SPYSKSPVSKRR 4
distal
150H RSSSP[Y/H]YSKSPVSKRR 2
proximal
152R RSSSPYS[K/R]KSPVSKRR 0
direct
149L RSSS[P/L]PYSKSPVSKRR 3
distal

PTM Site: 153S

Affected site:

Position: 153
Residue: S
Type: phosphorylation

Only loss of PTM site:

CSNK1E (probability p=0.874)
Site: 153S (phosphorylation)
Position in motif: 3

Other known mutations affecting this site

Mutation In sequence Distance Impact
156F SSSPYSKSPV[S/F]SKRRG 3
network-rewiring
149T SSS[P/T]PYSKSPVSKRRG 4
distal
147L S[S/L]SSPYSKSPVSKRRG 6
distal
148Y SS[S/Y]SPYSKSPVSKRRG 5
distal
150H SSSP[Y/H]YSKSPVSKRRG 3
distal
152R SSSPYS[K/R]KSPVSKRRG 1
proximal
149L SSS[P/L]PYSKSPVSKRRG 4
distal

PTM Site: 156S

Affected site:

Position: 156
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
156F PYSKSPV[S/F]SKRRGSQE 0
direct
150H P[Y/H]YSKSPVSKRRGSQE 6
distal
152R PYS[K/R]KSPVSKRRGSQE 4
distal
160W PYSKSPVSKRR[G/W]GSQE 4
distal

PTM Site: 161S

Affected site:

Position: 161
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
165H PVSKRRGSQEK[Q/H]QTKK 4
distal
156F PV[S/F]SKRRGSQEKQTKK 5
distal
167E PVSKRRGSQEKQT[K/E]KK 6
distal
163K PVSKRRGSQ[E/K]EKQTKK 2
proximal
160W PVSKRR[G/W]GSQEKQTKK 1
proximal

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