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Mutation:
BCLAF1 S156F
Summary
Isoform:
Position:
156
Ref:
S
Mutation:
F
PTM impact:
direct
PTM affected:
6
Kinases:
SRC
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 150Y
Affected site:
Position: 150
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145H | SS[R/H]RSSSPYSKSPVSK | 5 |
distal
|
| 145C | SS[R/C]RSSSPYSKSPVSK | 5 |
distal
|
| 156F | SSRSSSPYSKSPV[S/F]SK | 6 |
distal
|
| 149T | SSRSSS[P/T]PYSKSPVSK | 1 |
proximal
|
| 147L | SSRS[S/L]SSPYSKSPVSK | 3 |
distal
|
| 148Y | SSRSS[S/Y]SPYSKSPVSK | 2 |
proximal
|
| 150H | SSRSSSP[Y/H]YSKSPVSK | 0 |
direct
|
| 152R | SSRSSSPYS[K/R]KSPVSK | 2 |
proximal
|
| 144A | S[S/A]SRSSSPYSKSPVSK | 6 |
distal
|
| 149L | SSRSSS[P/L]PYSKSPVSK | 1 |
proximal
|
PTM Site: 151S
Affected site:
Position: 151
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145H | S[R/H]RSSSPYSKSPVSKR | 6 |
distal
|
| 145C | S[R/C]RSSSPYSKSPVSKR | 6 |
distal
|
| 156F | SRSSSPYSKSPV[S/F]SKR | 5 |
distal
|
| 149T | SRSSS[P/T]PYSKSPVSKR | 2 |
proximal
|
| 147L | SRS[S/L]SSPYSKSPVSKR | 4 |
distal
|
| 148Y | SRSS[S/Y]SPYSKSPVSKR | 3 |
network-rewiring
|
| 150H | SRSSSP[Y/H]YSKSPVSKR | 1 |
proximal
|
| 152R | SRSSSPYS[K/R]KSPVSKR | 1 |
proximal
|
| 149L | SRSSS[P/L]PYSKSPVSKR | 2 |
proximal
|
PTM Site: 152K
Affected site:
Position: 152
Residue: K
Type: acetylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 156F | RSSSPYSKSPV[S/F]SKRR | 4 |
distal
|
| 149T | RSSS[P/T]PYSKSPVSKRR | 3 |
distal
|
| 147L | RS[S/L]SSPYSKSPVSKRR | 5 |
distal
|
| 148Y | RSS[S/Y]SPYSKSPVSKRR | 4 |
distal
|
| 150H | RSSSP[Y/H]YSKSPVSKRR | 2 |
proximal
|
| 152R | RSSSPYS[K/R]KSPVSKRR | 0 |
direct
|
| 149L | RSSS[P/L]PYSKSPVSKRR | 3 |
distal
|
PTM Site: 153S
Affected site:
Position: 153
Residue: S
Type: phosphorylation
Only loss of PTM site:
CSNK1E (probability p=0.874)
Site: 153S (phosphorylation)
Position in motif: 3
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 156F | SSSPYSKSPV[S/F]SKRRG | 3 |
network-rewiring
|
| 149T | SSS[P/T]PYSKSPVSKRRG | 4 |
distal
|
| 147L | S[S/L]SSPYSKSPVSKRRG | 6 |
distal
|
| 148Y | SS[S/Y]SPYSKSPVSKRRG | 5 |
distal
|
| 150H | SSSP[Y/H]YSKSPVSKRRG | 3 |
distal
|
| 152R | SSSPYS[K/R]KSPVSKRRG | 1 |
proximal
|
| 149L | SSS[P/L]PYSKSPVSKRRG | 4 |
distal
|
PTM Site: 156S
Affected site:
Position: 156
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 156F | PYSKSPV[S/F]SKRRGSQE | 0 |
direct
|
| 150H | P[Y/H]YSKSPVSKRRGSQE | 6 |
distal
|
| 152R | PYS[K/R]KSPVSKRRGSQE | 4 |
distal
|
| 160W | PYSKSPVSKRR[G/W]GSQE | 4 |
distal
|
PTM Site: 161S
Affected site:
Position: 161
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 165H | PVSKRRGSQEK[Q/H]QTKK | 4 |
distal
|
| 156F | PV[S/F]SKRRGSQEKQTKK | 5 |
distal
|
| 167E | PVSKRRGSQEKQT[K/E]KK | 6 |
distal
|
| 163K | PVSKRRGSQ[E/K]EKQTKK | 2 |
proximal
|
| 160W | PVSKRR[G/W]GSQEKQTKK | 1 |
proximal
|
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