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Summary

Isoform:
Position:
145
Ref:
R
Mutation:
C
PTM impact:
network-rewiring
PTM affected:
7
Kinases:
SRC

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 138S

Affected site:

Position: 138
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134I RSY[R/I]RSSRSPRSSSSR 4
distal
137K RSYRSS[R/K]RSPRSSSSR 1
proximal
141L RSYRSSRSPR[S/L]SSSSR 3
distal
137M RSYRSS[R/M]RSPRSSSSR 1
proximal
144A RSYRSSRSPRSSS[S/A]SR 6
distal

PTM Site: 141S

Affected site:

Position: 141
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H RSSRSPRSSSS[R/H]RSSS 4
distal
145C RSSRSPRSSSS[R/C]RSSS 4
distal
147L RSSRSPRSSSSRS[S/L]SS 6
distal
137K RSS[R/K]RSPRSSSSRSSS 4
distal
141L RSSRSPR[S/L]SSSSRSSS 0
direct
137M RSS[R/M]RSPRSSSSRSSS 4
distal
144A RSSRSPRSSS[S/A]SRSSS 3
distal

PTM Site: 146S

Affected site:

Position: 146
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H PRSSSS[R/H]RSSSPYSKS 1
proximal
145C PRSSSS[R/C]RSSSPYSKS 1
proximal
149T PRSSSSRSSS[P/T]PYSKS 3
distal
147L PRSSSSRS[S/L]SSPYSKS 1
network-rewiring
148Y PRSSSSRSS[S/Y]SPYSKS 2
proximal
150H PRSSSSRSSSP[Y/H]YSKS 4
distal
141L PR[S/L]SSSSRSSSPYSKS 5
distal
152R PRSSSSRSSSPYS[K/R]KS 6
distal
144A PRSSS[S/A]SRSSSPYSKS 2
proximal
149L PRSSSSRSSS[P/L]PYSKS 3
distal

PTM Site: 148S

Affected site:

Position: 148
Residue: S
Type: phosphorylation

Best loss of PTM site:

AKT1 (probability p=0.985)
Site: 148S (phosphorylation)
Position in motif: -3
There are 12 other predicted losses:
  • CHEK2 (p=0.971)
  • CHEK1 (p=0.956)
  • CAMK2A (p=0.922)
  • PAK1 (p=0.919)
  • PRKAA1 (p=0.904)
  • RPS6KB1 (p=0.893)
  • RPS6KA1 (p=0.889)
  • CAMK4 (p=0.878)
  • PRKACA (p=0.877)
  • SGK1 (p=0.874)
  • PRKG1 (p=0.863)
  • PRKD1 (p=0.863)

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H SSSS[R/H]RSSSPYSKSPV 3
network-rewiring
145C SSSS[R/C]RSSSPYSKSPV 3
network-rewiring
149T SSSSRSSS[P/T]PYSKSPV 1
network-rewiring
147L SSSSRS[S/L]SSPYSKSPV 1
proximal
148Y SSSSRSS[S/Y]SPYSKSPV 0
direct
150H SSSSRSSSP[Y/H]YSKSPV 2
proximal
152R SSSSRSSSPYS[K/R]KSPV 4
distal
144A SSS[S/A]SRSSSPYSKSPV 4
distal
149L SSSSRSSS[P/L]PYSKSPV 1
network-rewiring

PTM Site: 150Y

Affected site:

Position: 150
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H SS[R/H]RSSSPYSKSPVSK 5
distal
145C SS[R/C]RSSSPYSKSPVSK 5
distal
156F SSRSSSPYSKSPV[S/F]SK 6
distal
149T SSRSSS[P/T]PYSKSPVSK 1
proximal
147L SSRS[S/L]SSPYSKSPVSK 3
distal
148Y SSRSS[S/Y]SPYSKSPVSK 2
proximal
150H SSRSSSP[Y/H]YSKSPVSK 0
direct
152R SSRSSSPYS[K/R]KSPVSK 2
proximal
144A S[S/A]SRSSSPYSKSPVSK 6
distal
149L SSRSSS[P/L]PYSKSPVSK 1
proximal

PTM Site: 151S

Affected site:

Position: 151
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145H S[R/H]RSSSPYSKSPVSKR 6
distal
145C S[R/C]RSSSPYSKSPVSKR 6
distal
156F SRSSSPYSKSPV[S/F]SKR 5
distal
149T SRSSS[P/T]PYSKSPVSKR 2
proximal
147L SRS[S/L]SSPYSKSPVSKR 4
distal
148Y SRSS[S/Y]SPYSKSPVSKR 3
network-rewiring
150H SRSSSP[Y/H]YSKSPVSKR 1
proximal
152R SRSSSPYS[K/R]KSPVSKR 1
proximal
149L SRSSS[P/L]PYSKSPVSKR 2
proximal

PTM Site: 152K

Affected site:

Position: 152
Residue: K
Type: acetylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
156F RSSSPYSKSPV[S/F]SKRR 4
distal
149T RSSS[P/T]PYSKSPVSKRR 3
distal
147L RS[S/L]SSPYSKSPVSKRR 5
distal
148Y RSS[S/Y]SPYSKSPVSKRR 4
distal
150H RSSSP[Y/H]YSKSPVSKRR 2
proximal
152R RSSSPYS[K/R]KSPVSKRR 0
direct
149L RSSS[P/L]PYSKSPVSKRR 3
distal

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