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Mutation:
BCLAF1 Y150H
Summary
Isoform:
Position:
150
Ref:
Y
Mutation:
H
PTM impact:
direct
PTM affected:
7
Kinases:
SRC
Clinical Information
Cancer types: (TCGA MC3)
LUSC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 146S
Affected site:
Position: 146
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
145H | PRSSSS[R/H]RSSSPYSKS | 1 |
proximal
|
145C | PRSSSS[R/C]RSSSPYSKS | 1 |
proximal
|
149T | PRSSSSRSSS[P/T]PYSKS | 3 |
distal
|
147L | PRSSSSRS[S/L]SSPYSKS | 1 |
network-rewiring
|
148Y | PRSSSSRSS[S/Y]SPYSKS | 2 |
proximal
|
150H | PRSSSSRSSSP[Y/H]YSKS | 4 |
distal
|
141L | PR[S/L]SSSSRSSSPYSKS | 5 |
distal
|
152R | PRSSSSRSSSPYS[K/R]KS | 6 |
distal
|
144A | PRSSS[S/A]SRSSSPYSKS | 2 |
proximal
|
149L | PRSSSSRSSS[P/L]PYSKS | 3 |
distal
|
PTM Site: 148S
Affected site:
Position: 148
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
145H | SSSS[R/H]RSSSPYSKSPV | 3 |
network-rewiring
|
145C | SSSS[R/C]RSSSPYSKSPV | 3 |
network-rewiring
|
149T | SSSSRSSS[P/T]PYSKSPV | 1 |
network-rewiring
|
147L | SSSSRS[S/L]SSPYSKSPV | 1 |
proximal
|
148Y | SSSSRSS[S/Y]SPYSKSPV | 0 |
direct
|
150H | SSSSRSSSP[Y/H]YSKSPV | 2 |
proximal
|
152R | SSSSRSSSPYS[K/R]KSPV | 4 |
distal
|
144A | SSS[S/A]SRSSSPYSKSPV | 4 |
distal
|
149L | SSSSRSSS[P/L]PYSKSPV | 1 |
network-rewiring
|
PTM Site: 150Y
Affected site:
Position: 150
Residue: Y
Type: phosphorylation
Impact:
directOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
145H | SS[R/H]RSSSPYSKSPVSK | 5 |
distal
|
145C | SS[R/C]RSSSPYSKSPVSK | 5 |
distal
|
156F | SSRSSSPYSKSPV[S/F]SK | 6 |
distal
|
149T | SSRSSS[P/T]PYSKSPVSK | 1 |
proximal
|
147L | SSRS[S/L]SSPYSKSPVSK | 3 |
distal
|
148Y | SSRSS[S/Y]SPYSKSPVSK | 2 |
proximal
|
150H | SSRSSSP[Y/H]YSKSPVSK | 0 |
direct
|
152R | SSRSSSPYS[K/R]KSPVSK | 2 |
proximal
|
144A | S[S/A]SRSSSPYSKSPVSK | 6 |
distal
|
149L | SSRSSS[P/L]PYSKSPVSK | 1 |
proximal
|
PTM Site: 151S
Affected site:
Position: 151
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
145H | S[R/H]RSSSPYSKSPVSKR | 6 |
distal
|
145C | S[R/C]RSSSPYSKSPVSKR | 6 |
distal
|
156F | SRSSSPYSKSPV[S/F]SKR | 5 |
distal
|
149T | SRSSS[P/T]PYSKSPVSKR | 2 |
proximal
|
147L | SRS[S/L]SSPYSKSPVSKR | 4 |
distal
|
148Y | SRSS[S/Y]SPYSKSPVSKR | 3 |
network-rewiring
|
150H | SRSSSP[Y/H]YSKSPVSKR | 1 |
proximal
|
152R | SRSSSPYS[K/R]KSPVSKR | 1 |
proximal
|
149L | SRSSS[P/L]PYSKSPVSKR | 2 |
proximal
|
PTM Site: 152K
Affected site:
Position: 152
Residue: K
Type: acetylation
Impact:
proximalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
156F | RSSSPYSKSPV[S/F]SKRR | 4 |
distal
|
149T | RSSS[P/T]PYSKSPVSKRR | 3 |
distal
|
147L | RS[S/L]SSPYSKSPVSKRR | 5 |
distal
|
148Y | RSS[S/Y]SPYSKSPVSKRR | 4 |
distal
|
150H | RSSSP[Y/H]YSKSPVSKRR | 2 |
proximal
|
152R | RSSSPYS[K/R]KSPVSKRR | 0 |
direct
|
149L | RSSS[P/L]PYSKSPVSKRR | 3 |
distal
|
PTM Site: 153S
Affected site:
Position: 153
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
156F | SSSPYSKSPV[S/F]SKRRG | 3 |
network-rewiring
|
149T | SSS[P/T]PYSKSPVSKRRG | 4 |
distal
|
147L | S[S/L]SSPYSKSPVSKRRG | 6 |
distal
|
148Y | SS[S/Y]SPYSKSPVSKRRG | 5 |
distal
|
150H | SSSP[Y/H]YSKSPVSKRRG | 3 |
distal
|
152R | SSSPYS[K/R]KSPVSKRRG | 1 |
proximal
|
149L | SSS[P/L]PYSKSPVSKRRG | 4 |
distal
|
PTM Site: 156S
Affected site:
Position: 156
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
Mutation | In sequence | Distance | Impact |
---|---|---|---|
156F | PYSKSPV[S/F]SKRRGSQE | 0 |
direct
|
150H | P[Y/H]YSKSPVSKRRGSQE | 6 |
distal
|
152R | PYS[K/R]KSPVSKRRGSQE | 4 |
distal
|
160W | PYSKSPVSKRR[G/W]GSQE | 4 |
distal
|
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