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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 Q16R

Summary

Isoform:
NM_001126113
Position:
16
Ref:
Q
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
CSNK1D, ATM, CSNK1A1, PRKDC, TP53RK, CDK5, MAPK3, CHEK1, NUAK1, PRKDC, DYRK1A, CHEK2, MAPK1, ATM, DNA-PK, STK11, SMG1, ATR, BTK, MAPK14, CK1 group, CSNK2B, CSNK1D, CSNK2A1, TTK, CSNK1A1, CHEK1, VRK1, PRKAA1, PRKDC, DAPK1, ATR, CHEK2, CSNK1D, MAPK8, PLK3, CSNK1A1, CHEK1, PRKAA1, CDK5, MAPK9, PRKDC, MAPKAPK2, CHK1, ATM, CHK2, DAPK1, DAPK3, ATR, STK17A, CHEK2

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 9S

Affected site:

Position: 9
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
14V EEPQSDPSVEPP[L/V]LSQ 5
distal
13L EEPQSDPSVEP[P/L]PLSQ 4
distal
13R EEPQSDPSVEP[P/R]PLSQ 4
distal
13S EEPQSDPSVEP[P/S]PLSQ 4
distal
12L EEPQSDPSVE[P/L]PPLSQ 3
distal
12R EEPQSDPSVE[P/R]PPLSQ 3
distal
12H EEPQSDPSVE[P/H]PPLSQ 3
distal
11Q EEPQSDPSV[E/Q]EPPLSQ 2
proximal
11K EEPQSDPSV[E/K]EPPLSQ 2
network-rewiring
10G EEPQSDPS[V/G]VEPPLSQ 1
proximal
10F EEPQSDPS[V/F]VEPPLSQ 1
proximal
10L EEPQSDPS[V/L]VEPPLSQ 1
network-rewiring
10I EEPQSDPS[V/I]VEPPLSQ 1
proximal
9R EEPQSDP[S/R]SVEPPLSQ 0
direct
9N EEPQSDP[S/N]SVEPPLSQ 0
direct
8L EEPQSD[P/L]PSVEPPLSQ 1
proximal
8T EEPQSD[P/T]PSVEPPLSQ 1
proximal
7E EEPQS[D/E]DPSVEPPLSQ 2
proximal
7H EEPQS[D/H]DPSVEPPLSQ 2
proximal
5R EEP[Q/R]QSDPSVEPPLSQ 4
distal
4L EE[P/L]PQSDPSVEPPLSQ 5
distal
4R EE[P/R]PQSDPSVEPPLSQ 5
network-rewiring
3G E[E/G]EPQSDPSVEPPLSQ 6
distal
3Q E[E/Q]EPQSDPSVEPPLSQ 6
distal
3K E[E/K]EPQSDPSVEPPLSQ 6
distal

PTM Site: 15S

Affected site:

Position: 15
Residue: S
Type: phosphorylation

Best gain of PTM site:

PRKACA (probability p=0.965)
Site: 18T (phosphorylation)
Position in motif: -2
There are 3 other predicted gains:
  • PRKCD (p=0.939)
  • AURKB (p=0.886)
  • ROCK1 (p=0.883)

Best loss of PTM site:

PRKDC (probability p=0.996)
Site: 15S (phosphorylation)
Position in motif: 1
There is 1 other predicted loss:
  • ATM (p=0.994)

Other known mutations affecting this site

Mutation In sequence Distance Impact
20L PSVEPPLSQETF[S/L]SDL 5
distal
20P PSVEPPLSQETF[S/P]SDL 5
distal
16H PSVEPPLS[Q/H]QETFSDL 1
network-rewiring
16R PSVEPPLS[Q/R]QETFSDL 1
network-rewiring
14V PSVEPP[L/V]LSQETFSDL 1
proximal
13L PSVEP[P/L]PLSQETFSDL 2
proximal
13R PSVEP[P/R]PLSQETFSDL 2
network-rewiring
13S PSVEP[P/S]PLSQETFSDL 2
proximal
12L PSVE[P/L]PPLSQETFSDL 3
distal
12R PSVE[P/R]PPLSQETFSDL 3
network-rewiring
12H PSVE[P/H]PPLSQETFSDL 3
distal
11Q PSV[E/Q]EPPLSQETFSDL 4
distal
11K PSV[E/K]EPPLSQETFSDL 4
distal
10G PS[V/G]VEPPLSQETFSDL 5
distal
10F PS[V/F]VEPPLSQETFSDL 5
distal
10L PS[V/L]VEPPLSQETFSDL 5
distal
10I PS[V/I]VEPPLSQETFSDL 5
distal
9R P[S/R]SVEPPLSQETFSDL 6
distal
9N P[S/N]SVEPPLSQETFSDL 6
distal

PTM Site: 18T

Affected site:

Position: 18
Residue: T
Type: phosphorylation

Best gain of PTM site:

PRKACA (probability p=0.965)
Site: 18T (phosphorylation)
Position in motif: -2
There are 3 other predicted gains:
  • PRKCD (p=0.939)
  • AURKB (p=0.886)
  • ROCK1 (p=0.883)

Best loss of PTM site:

PRKDC (probability p=0.996)
Site: 15S (phosphorylation)
Position in motif: 1
There is 1 other predicted loss:
  • ATM (p=0.994)

Other known mutations affecting this site

Mutation In sequence Distance Impact
20L EPPLSQETF[S/L]SDLWKL 2
proximal
20P EPPLSQETF[S/P]SDLWKL 2
proximal
16H EPPLS[Q/H]QETFSDLWKL 2
proximal
16R EPPLS[Q/R]QETFSDLWKL 2
network-rewiring
14V EPP[L/V]LSQETFSDLWKL 4
distal
13L EP[P/L]PLSQETFSDLWKL 5
distal
13R EP[P/R]PLSQETFSDLWKL 5
network-rewiring
13S EP[P/S]PLSQETFSDLWKL 5
distal
12L E[P/L]PPLSQETFSDLWKL 6
distal
12R E[P/R]PPLSQETFSDLWKL 6
distal
12H E[P/H]PPLSQETFSDLWKL 6
distal

PTM Site: 20S

Affected site:

Position: 20
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
26I PLSQETFSDLWKL[L/I]LP 6
distal
20L PLSQETF[S/L]SDLWKLLP 0
direct
20P PLSQETF[S/P]SDLWKLLP 0
direct
16H PLS[Q/H]QETFSDLWKLLP 4
distal
16R PLS[Q/R]QETFSDLWKLLP 4
distal
14V P[L/V]LSQETFSDLWKLLP 6
distal

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