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Mutation:
TP53 P13L
Summary
Isoform:
Position:
13
Ref:
P
Mutation:
L
PTM impact:
proximal
PTM affected:
5
Kinases:
CSNK1A1,
CSNK1A1,
ATM,
PRKDC,
CSNK1D,
MAPK14,
DYRK1A,
ATM,
BTK,
CDK5,
MAPK3,
ATR,
DNA-PK,
STK11,
TP53RK,
CHEK1,
PRKDC,
SMG1,
CHEK2,
NUAK1,
MAPK1, CK1 group,
VRK1,
CSNK2A1,
CSNK1A1,
PRKAA1,
ATR,
TTK,
CSNK2B,
CHEK1,
PRKDC,
CHEK2,
DAPK1,
CSNK1D,
CSNK1A1,
PRKAA1,
ATM,
PLK3,
CHK1,
ATR,
STK17A,
CDK5,
DAPK3,
MAPK9,
CHK2,
CHEK1,
PRKDC,
MAPK8,
CHEK2,
MAPKAPK2,
DAPK1,
CSNK1D
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 6S
Affected site:
Position: 6
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 12L | --MEEPQSDPSVE[P/L]PP | 6 |
distal
|
| 12R | --MEEPQSDPSVE[P/R]PP | 6 |
distal
|
| 12H | --MEEPQSDPSVE[P/H]PP | 6 |
distal
|
| 11Q | --MEEPQSDPSV[E/Q]EPP | 5 |
distal
|
| 11K | --MEEPQSDPSV[E/K]EPP | 5 |
distal
|
| 10G | --MEEPQSDPS[V/G]VEPP | 4 |
distal
|
| 10F | --MEEPQSDPS[V/F]VEPP | 4 |
distal
|
| 10L | --MEEPQSDPS[V/L]VEPP | 4 |
distal
|
| 10I | --MEEPQSDPS[V/I]VEPP | 4 |
distal
|
| 9R | --MEEPQSDP[S/R]SVEPP | 3 |
distal
|
| 9N | --MEEPQSDP[S/N]SVEPP | 3 |
distal
|
| 8L | --MEEPQSD[P/L]PSVEPP | 2 |
proximal
|
| 8T | --MEEPQSD[P/T]PSVEPP | 2 |
proximal
|
| 7E | --MEEPQS[D/E]DPSVEPP | 1 |
proximal
|
| 7H | --MEEPQS[D/H]DPSVEPP | 1 |
proximal
|
| 5R | --MEEP[Q/R]QSDPSVEPP | 1 |
proximal
|
| 4L | --MEE[P/L]PQSDPSVEPP | 2 |
proximal
|
| 4R | --MEE[P/R]PQSDPSVEPP | 2 |
network-rewiring
|
| 3G | --ME[E/G]EPQSDPSVEPP | 3 |
distal
|
| 3Q | --ME[E/Q]EPQSDPSVEPP | 3 |
distal
|
| 3K | --ME[E/K]EPQSDPSVEPP | 3 |
distal
|
| 2G | --M[E/G]EEPQSDPSVEPP | 4 |
distal
|
| 2K | --M[E/K]EEPQSDPSVEPP | 4 |
distal
|
| 1V | --[M/V]MEEPQSDPSVEPP | 5 |
distal
|
PTM Site: 9S
Affected site:
Position: 9
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 14V | EEPQSDPSVEPP[L/V]LSQ | 5 |
distal
|
| 13L | EEPQSDPSVEP[P/L]PLSQ | 4 |
distal
|
| 13R | EEPQSDPSVEP[P/R]PLSQ | 4 |
distal
|
| 13S | EEPQSDPSVEP[P/S]PLSQ | 4 |
distal
|
| 12L | EEPQSDPSVE[P/L]PPLSQ | 3 |
distal
|
| 12R | EEPQSDPSVE[P/R]PPLSQ | 3 |
distal
|
| 12H | EEPQSDPSVE[P/H]PPLSQ | 3 |
distal
|
| 11Q | EEPQSDPSV[E/Q]EPPLSQ | 2 |
proximal
|
| 11K | EEPQSDPSV[E/K]EPPLSQ | 2 |
network-rewiring
|
| 10G | EEPQSDPS[V/G]VEPPLSQ | 1 |
proximal
|
| 10F | EEPQSDPS[V/F]VEPPLSQ | 1 |
proximal
|
| 10L | EEPQSDPS[V/L]VEPPLSQ | 1 |
network-rewiring
|
| 10I | EEPQSDPS[V/I]VEPPLSQ | 1 |
proximal
|
| 9R | EEPQSDP[S/R]SVEPPLSQ | 0 |
direct
|
| 9N | EEPQSDP[S/N]SVEPPLSQ | 0 |
direct
|
| 8L | EEPQSD[P/L]PSVEPPLSQ | 1 |
proximal
|
| 8T | EEPQSD[P/T]PSVEPPLSQ | 1 |
proximal
|
| 7E | EEPQS[D/E]DPSVEPPLSQ | 2 |
proximal
|
| 7H | EEPQS[D/H]DPSVEPPLSQ | 2 |
proximal
|
| 5R | EEP[Q/R]QSDPSVEPPLSQ | 4 |
distal
|
| 4L | EE[P/L]PQSDPSVEPPLSQ | 5 |
distal
|
| 4R | EE[P/R]PQSDPSVEPPLSQ | 5 |
network-rewiring
|
| 3G | E[E/G]EPQSDPSVEPPLSQ | 6 |
distal
|
| 3Q | E[E/Q]EPQSDPSVEPPLSQ | 6 |
distal
|
| 3K | E[E/K]EPQSDPSVEPPLSQ | 6 |
distal
|
PTM Site: 15S
Affected site:
Position: 15
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 20L | PSVEPPLSQETF[S/L]SDL | 5 |
distal
|
| 20P | PSVEPPLSQETF[S/P]SDL | 5 |
distal
|
| 16H | PSVEPPLS[Q/H]QETFSDL | 1 |
network-rewiring
|
| 16R | PSVEPPLS[Q/R]QETFSDL | 1 |
network-rewiring
|
| 14V | PSVEPP[L/V]LSQETFSDL | 1 |
proximal
|
| 13L | PSVEP[P/L]PLSQETFSDL | 2 |
proximal
|
| 13R | PSVEP[P/R]PLSQETFSDL | 2 |
network-rewiring
|
| 13S | PSVEP[P/S]PLSQETFSDL | 2 |
proximal
|
| 12L | PSVE[P/L]PPLSQETFSDL | 3 |
distal
|
| 12R | PSVE[P/R]PPLSQETFSDL | 3 |
network-rewiring
|
| 12H | PSVE[P/H]PPLSQETFSDL | 3 |
distal
|
| 11Q | PSV[E/Q]EPPLSQETFSDL | 4 |
distal
|
| 11K | PSV[E/K]EPPLSQETFSDL | 4 |
distal
|
| 10G | PS[V/G]VEPPLSQETFSDL | 5 |
distal
|
| 10F | PS[V/F]VEPPLSQETFSDL | 5 |
distal
|
| 10L | PS[V/L]VEPPLSQETFSDL | 5 |
distal
|
| 10I | PS[V/I]VEPPLSQETFSDL | 5 |
distal
|
| 9R | P[S/R]SVEPPLSQETFSDL | 6 |
distal
|
| 9N | P[S/N]SVEPPLSQETFSDL | 6 |
distal
|
PTM Site: 18T
Affected site:
Position: 18
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 20L | EPPLSQETF[S/L]SDLWKL | 2 |
proximal
|
| 20P | EPPLSQETF[S/P]SDLWKL | 2 |
proximal
|
| 16H | EPPLS[Q/H]QETFSDLWKL | 2 |
proximal
|
| 16R | EPPLS[Q/R]QETFSDLWKL | 2 |
network-rewiring
|
| 14V | EPP[L/V]LSQETFSDLWKL | 4 |
distal
|
| 13L | EP[P/L]PLSQETFSDLWKL | 5 |
distal
|
| 13R | EP[P/R]PLSQETFSDLWKL | 5 |
network-rewiring
|
| 13S | EP[P/S]PLSQETFSDLWKL | 5 |
distal
|
| 12L | E[P/L]PPLSQETFSDLWKL | 6 |
distal
|
| 12R | E[P/R]PPLSQETFSDLWKL | 6 |
distal
|
| 12H | E[P/H]PPLSQETFSDLWKL | 6 |
distal
|
PTM Site: 20S
Affected site:
Position: 20
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 26I | PLSQETFSDLWKL[L/I]LP | 6 |
distal
|
| 20L | PLSQETF[S/L]SDLWKLLP | 0 |
direct
|
| 20P | PLSQETF[S/P]SDLWKLLP | 0 |
direct
|
| 16H | PLS[Q/H]QETFSDLWKLLP | 4 |
distal
|
| 16R | PLS[Q/R]QETFSDLWKLLP | 4 |
distal
|
| 14V | P[L/V]LSQETFSDLWKLLP | 6 |
distal
|
External references
dbSNP:
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