TP53 V10I

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Mutation:

Summary

Isoform:

NM_001126113

Position:

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

CSNK1A1, PRKDC, CSNK1D, CSNK1A1, ATM, STK11, MAPK14, ATR, CHEK1, BTK, CDK5, DNA-PK, NUAK1, DYRK1A, ATM, CHEK2, PRKDC, MAPK1, TP53RK, MAPK3, SMG1

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 6S

Affected site:

Position: 6

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
12L	--MEEPQSDPSVE[P/L]PP	6	distal
12R	--MEEPQSDPSVE[P/R]PP	6	distal
12H	--MEEPQSDPSVE[P/H]PP	6	distal
11Q	--MEEPQSDPSV[E/Q]EPP	5	distal
11K	--MEEPQSDPSV[E/K]EPP	5	distal
10G	--MEEPQSDPS[V/G]VEPP	4	distal
10F	--MEEPQSDPS[V/F]VEPP	4	distal
10L	--MEEPQSDPS[V/L]VEPP	4	distal
10I	--MEEPQSDPS[V/I]VEPP	4	distal
9R	--MEEPQSDP[S/R]SVEPP	3	distal
9N	--MEEPQSDP[S/N]SVEPP	3	distal
8L	--MEEPQSD[P/L]PSVEPP	2	proximal
8T	--MEEPQSD[P/T]PSVEPP	2	proximal
7E	--MEEPQS[D/E]DPSVEPP	1	proximal
7H	--MEEPQS[D/H]DPSVEPP	1	proximal
5R	--MEEP[Q/R]QSDPSVEPP	1	proximal
4L	--MEE[P/L]PQSDPSVEPP	2	proximal
4R	--MEE[P/R]PQSDPSVEPP	2	network-rewiring
3G	--ME[E/G]EPQSDPSVEPP	3	distal
3Q	--ME[E/Q]EPQSDPSVEPP	3	distal
3K	--ME[E/K]EPQSDPSVEPP	3	distal
2G	--M[E/G]EEPQSDPSVEPP	4	distal
2K	--M[E/K]EEPQSDPSVEPP	4	distal
1V	--[M/V]MEEPQSDPSVEPP	5	distal

PTM Site: 9S

Affected site:

Position: 9

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
14V	EEPQSDPSVEPP[L/V]LSQ	5	distal
13L	EEPQSDPSVEP[P/L]PLSQ	4	distal
13R	EEPQSDPSVEP[P/R]PLSQ	4	distal
13S	EEPQSDPSVEP[P/S]PLSQ	4	distal
12L	EEPQSDPSVE[P/L]PPLSQ	3	distal
12R	EEPQSDPSVE[P/R]PPLSQ	3	distal
12H	EEPQSDPSVE[P/H]PPLSQ	3	distal
11Q	EEPQSDPSV[E/Q]EPPLSQ	2	proximal
11K	EEPQSDPSV[E/K]EPPLSQ	2	network-rewiring
10G	EEPQSDPS[V/G]VEPPLSQ	1	proximal
10F	EEPQSDPS[V/F]VEPPLSQ	1	proximal
10L	EEPQSDPS[V/L]VEPPLSQ	1	network-rewiring
10I	EEPQSDPS[V/I]VEPPLSQ	1	proximal
9R	EEPQSDP[S/R]SVEPPLSQ	0	direct
9N	EEPQSDP[S/N]SVEPPLSQ	0	direct
8L	EEPQSD[P/L]PSVEPPLSQ	1	proximal
8T	EEPQSD[P/T]PSVEPPLSQ	1	proximal
7E	EEPQS[D/E]DPSVEPPLSQ	2	proximal
7H	EEPQS[D/H]DPSVEPPLSQ	2	proximal
5R	EEP[Q/R]QSDPSVEPPLSQ	4	distal
4L	EE[P/L]PQSDPSVEPPLSQ	5	distal
4R	EE[P/R]PQSDPSVEPPLSQ	5	network-rewiring
3G	E[E/G]EPQSDPSVEPPLSQ	6	distal
3Q	E[E/Q]EPQSDPSVEPPLSQ	6	distal
3K	E[E/K]EPQSDPSVEPPLSQ	6	distal

PTM Site: 15S

Affected site:

Position: 15

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
20L	PSVEPPLSQETF[S/L]SDL	5	distal
20P	PSVEPPLSQETF[S/P]SDL	5	distal
16H	PSVEPPLS[Q/H]QETFSDL	1	network-rewiring
16R	PSVEPPLS[Q/R]QETFSDL	1	network-rewiring
14V	PSVEPP[L/V]LSQETFSDL	1	proximal
13L	PSVEP[P/L]PLSQETFSDL	2	proximal
13R	PSVEP[P/R]PLSQETFSDL	2	network-rewiring
13S	PSVEP[P/S]PLSQETFSDL	2	proximal
12L	PSVE[P/L]PPLSQETFSDL	3	distal
12R	PSVE[P/R]PPLSQETFSDL	3	network-rewiring
12H	PSVE[P/H]PPLSQETFSDL	3	distal
11Q	PSV[E/Q]EPPLSQETFSDL	4	distal
11K	PSV[E/K]EPPLSQETFSDL	4	distal
10G	PS[V/G]VEPPLSQETFSDL	5	distal
10F	PS[V/F]VEPPLSQETFSDL	5	distal
10L	PS[V/L]VEPPLSQETFSDL	5	distal
10I	PS[V/I]VEPPLSQETFSDL	5	distal
9R	P[S/R]SVEPPLSQETFSDL	6	distal
9N	P[S/N]SVEPPLSQETFSDL	6	distal

External references

dbSNP:

rs535274413

If you have any questions or feedback about this mutation: