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Mutation:
TP53 E28V
Summary
Isoform:
Position:
28
Ref:
E
Mutation:
V
PTM impact:
distal
PTM affected:
2
Kinases:
GSK-3 group, CDK group,
MAPK12,
CDK7,
ATM,
CDK9,
MAPK14,
PRKDC,
GSK3B,
CDK5
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 24K
Affected site:
Position: 24
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 29K | ETFSDLWKLLPE[N/K]NNV | 5 |
distal
|
| 29T | ETFSDLWKLLPE[N/T]NNV | 5 |
distal
|
| 29D | ETFSDLWKLLPE[N/D]NNV | 5 |
distal
|
| 28V | ETFSDLWKLLP[E/V]ENNV | 4 |
distal
|
| 27L | ETFSDLWKLL[P/L]PENNV | 3 |
distal
|
| 27R | ETFSDLWKLL[P/R]PENNV | 3 |
distal
|
| 27S | ETFSDLWKLL[P/S]PENNV | 3 |
distal
|
| 27T | ETFSDLWKLL[P/T]PENNV | 3 |
distal
|
| 26I | ETFSDLWKL[L/I]LPENNV | 2 |
proximal
|
| 20L | ETF[S/L]SDLWKLLPENNV | 4 |
distal
|
| 20P | ETF[S/P]SDLWKLLPENNV | 4 |
distal
|
| 30I | ETFSDLWKLLPEN[N/I]NV | 6 |
distal
|
PTM Site: 33S
Affected site:
Position: 33
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 39V | LPENNVLSPLPSQ[A/V]AM | 6 |
distal
|
| 38P | LPENNVLSPLPS[Q/P]QAM | 5 |
distal
|
| 37F | LPENNVLSPLP[S/F]SQAM | 4 |
distal
|
| 36L | LPENNVLSPL[P/L]PSQAM | 3 |
distal
|
| 36Q | LPENNVLSPL[P/Q]PSQAM | 3 |
distal
|
| 35M | LPENNVLSP[L/M]LPSQAM | 2 |
proximal
|
| 34L | LPENNVLS[P/L]PLPSQAM | 1 |
network-rewiring
|
| 34R | LPENNVLS[P/R]PLPSQAM | 1 |
network-rewiring
|
| 34S | LPENNVLS[P/S]PLPSQAM | 1 |
network-rewiring
|
| 34A | LPENNVLS[P/A]PLPSQAM | 1 |
network-rewiring
|
| 34T | LPENNVLS[P/T]PLPSQAM | 1 |
network-rewiring
|
| 33F | LPENNVL[S/F]SPLPSQAM | 0 |
direct
|
| 33Y | LPENNVL[S/Y]SPLPSQAM | 0 |
direct
|
| 31F | LPENN[V/F]VLSPLPSQAM | 2 |
proximal
|
| 31I | LPENN[V/I]VLSPLPSQAM | 2 |
proximal
|
| 29K | LPE[N/K]NNVLSPLPSQAM | 4 |
distal
|
| 29T | LPE[N/T]NNVLSPLPSQAM | 4 |
distal
|
| 29D | LPE[N/D]NNVLSPLPSQAM | 4 |
distal
|
| 28V | LP[E/V]ENNVLSPLPSQAM | 5 |
distal
|
| 27L | L[P/L]PENNVLSPLPSQAM | 6 |
distal
|
| 27R | L[P/R]PENNVLSPLPSQAM | 6 |
distal
|
| 27S | L[P/S]PENNVLSPLPSQAM | 6 |
distal
|
| 27T | L[P/T]PENNVLSPLPSQAM | 6 |
distal
|
| 30I | LPEN[N/I]NVLSPLPSQAM | 3 |
distal
|
External references
dbSNP:
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