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Mutation:
TP53 P34A
Summary
Isoform:
Position:
34
Ref:
P
Mutation:
A
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
GSK-3 group, CDK group,
CDK9,
MAPK12,
GSK3B,
ATM,
CDK7,
CDK5,
MAPK14,
PRKDC,
CSNK1A1,
MAPKAPK5,
CHEK1,
ATM,
DNA-PK,
PRKDC,
CHEK2,
ATR
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 33S
Affected site:
Position: 33
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.955)
Site: 33S (phosphorylation)
Position in motif: 1
There are 9 other predicted
losses:
- MAPK3 (p=0.951)
- MAPK14 (p=0.943)
- CDK5 (p=0.935)
- CDK1 (p=0.921)
- MAPK11 (p=0.911)
- CDK2 (p=0.908)
- CDK6 (p=0.889)
- CDK4 (p=0.884)
- CDK7 (p=0.862)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 39V | LPENNVLSPLPSQ[A/V]AM | 6 |
distal
|
| 38P | LPENNVLSPLPS[Q/P]QAM | 5 |
distal
|
| 37F | LPENNVLSPLP[S/F]SQAM | 4 |
distal
|
| 36L | LPENNVLSPL[P/L]PSQAM | 3 |
distal
|
| 36Q | LPENNVLSPL[P/Q]PSQAM | 3 |
distal
|
| 35M | LPENNVLSP[L/M]LPSQAM | 2 |
proximal
|
| 34L | LPENNVLS[P/L]PLPSQAM | 1 |
network-rewiring
|
| 34R | LPENNVLS[P/R]PLPSQAM | 1 |
network-rewiring
|
| 34S | LPENNVLS[P/S]PLPSQAM | 1 |
network-rewiring
|
| 34A | LPENNVLS[P/A]PLPSQAM | 1 |
network-rewiring
|
| 34T | LPENNVLS[P/T]PLPSQAM | 1 |
network-rewiring
|
| 33F | LPENNVL[S/F]SPLPSQAM | 0 |
direct
|
| 33Y | LPENNVL[S/Y]SPLPSQAM | 0 |
direct
|
| 31F | LPENN[V/F]VLSPLPSQAM | 2 |
proximal
|
| 31I | LPENN[V/I]VLSPLPSQAM | 2 |
proximal
|
| 29K | LPE[N/K]NNVLSPLPSQAM | 4 |
distal
|
| 29T | LPE[N/T]NNVLSPLPSQAM | 4 |
distal
|
| 29D | LPE[N/D]NNVLSPLPSQAM | 4 |
distal
|
| 28V | LP[E/V]ENNVLSPLPSQAM | 5 |
distal
|
| 27L | L[P/L]PENNVLSPLPSQAM | 6 |
distal
|
| 27R | L[P/R]PENNVLSPLPSQAM | 6 |
distal
|
| 27S | L[P/S]PENNVLSPLPSQAM | 6 |
distal
|
| 27T | L[P/T]PENNVLSPLPSQAM | 6 |
distal
|
| 30I | LPEN[N/I]NVLSPLPSQAM | 3 |
distal
|
PTM Site: 37S
Affected site:
Position: 37
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 43F | NVLSPLPSQAMDD[L/F]LM | 6 |
distal
|
| 43M | NVLSPLPSQAMDD[L/M]LM | 6 |
distal
|
| 42G | NVLSPLPSQAMD[D/G]DLM | 5 |
distal
|
| 41G | NVLSPLPSQAM[D/G]DDLM | 4 |
distal
|
| 41N | NVLSPLPSQAM[D/N]DDLM | 4 |
distal
|
| 39V | NVLSPLPSQ[A/V]AMDDLM | 2 |
proximal
|
| 38P | NVLSPLPS[Q/P]QAMDDLM | 1 |
network-rewiring
|
| 37F | NVLSPLP[S/F]SQAMDDLM | 0 |
direct
|
| 36L | NVLSPL[P/L]PSQAMDDLM | 1 |
proximal
|
| 36Q | NVLSPL[P/Q]PSQAMDDLM | 1 |
proximal
|
| 35M | NVLSP[L/M]LPSQAMDDLM | 2 |
proximal
|
| 34L | NVLS[P/L]PLPSQAMDDLM | 3 |
network-rewiring
|
| 34R | NVLS[P/R]PLPSQAMDDLM | 3 |
network-rewiring
|
| 34S | NVLS[P/S]PLPSQAMDDLM | 3 |
distal
|
| 34A | NVLS[P/A]PLPSQAMDDLM | 3 |
distal
|
| 34T | NVLS[P/T]PLPSQAMDDLM | 3 |
distal
|
| 33F | NVL[S/F]SPLPSQAMDDLM | 4 |
distal
|
| 33Y | NVL[S/Y]SPLPSQAMDDLM | 4 |
distal
|
| 31F | N[V/F]VLSPLPSQAMDDLM | 6 |
distal
|
| 31I | N[V/I]VLSPLPSQAMDDLM | 6 |
distal
|
External references
dbSNP:
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