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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 P34R

Summary

Isoform:
NM_001126113
Position:
34
Ref:
P
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
CDK group, GSK-3 group, PRKDC, CDK7, CDK9, CDK5, MAPK12, GSK3B, ATM, MAPK14, PRKDC, ATR, CHEK1, CSNK1A1, MAPKAPK5, DNA-PK, CHEK2, ATM

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 33S

Affected site:

Position: 33
Residue: S
Type: phosphorylation

Best gain of PTM site:

CHEK1 (probability p=0.993)
Site: 37S (phosphorylation)
Position in motif: -3
There are 9 other predicted gains:
  • AKT1 (p=0.984)
  • PRKACA (p=0.964)
  • RPS6KA1 (p=0.953)
  • PRKCE (p=0.935)
  • CAMK2A (p=0.929)
  • PRKCD (p=0.887)
  • CAMK1 (p=0.882)
  • MAPKAPK2 (p=0.879)
  • PRKAA1 (p=0.877)

Best loss of PTM site:

MAPK1 (probability p=0.955)
Site: 33S (phosphorylation)
Position in motif: 1
There are 9 other predicted losses:
  • MAPK3 (p=0.951)
  • MAPK14 (p=0.943)
  • CDK5 (p=0.935)
  • CDK1 (p=0.921)
  • MAPK11 (p=0.913)
  • CDK2 (p=0.908)
  • CDK6 (p=0.889)
  • CDK4 (p=0.884)
  • CDK7 (p=0.862)

Other known mutations affecting this site

Mutation In sequence Distance Impact
39V LPENNVLSPLPSQ[A/V]AM 6
distal
38P LPENNVLSPLPS[Q/P]QAM 5
distal
37F LPENNVLSPLP[S/F]SQAM 4
distal
36L LPENNVLSPL[P/L]PSQAM 3
distal
36Q LPENNVLSPL[P/Q]PSQAM 3
distal
35M LPENNVLSP[L/M]LPSQAM 2
proximal
34L LPENNVLS[P/L]PLPSQAM 1
network-rewiring
34R LPENNVLS[P/R]PLPSQAM 1
network-rewiring
34S LPENNVLS[P/S]PLPSQAM 1
network-rewiring
34A LPENNVLS[P/A]PLPSQAM 1
network-rewiring
34T LPENNVLS[P/T]PLPSQAM 1
network-rewiring
33F LPENNVL[S/F]SPLPSQAM 0
direct
33Y LPENNVL[S/Y]SPLPSQAM 0
direct
31F LPENN[V/F]VLSPLPSQAM 2
proximal
31I LPENN[V/I]VLSPLPSQAM 2
proximal
29K LPE[N/K]NNVLSPLPSQAM 4
distal
29T LPE[N/T]NNVLSPLPSQAM 4
distal
29D LPE[N/D]NNVLSPLPSQAM 4
distal
28V LP[E/V]ENNVLSPLPSQAM 5
distal
27L L[P/L]PENNVLSPLPSQAM 6
distal
27R L[P/R]PENNVLSPLPSQAM 6
distal
27S L[P/S]PENNVLSPLPSQAM 6
distal
27T L[P/T]PENNVLSPLPSQAM 6
distal
30I LPEN[N/I]NVLSPLPSQAM 3
distal

PTM Site: 37S

Affected site:

Position: 37
Residue: S
Type: phosphorylation

Best gain of PTM site:

CHEK1 (probability p=0.993)
Site: 37S (phosphorylation)
Position in motif: -3
There are 9 other predicted gains:
  • AKT1 (p=0.984)
  • PRKACA (p=0.964)
  • RPS6KA1 (p=0.953)
  • PRKCE (p=0.935)
  • CAMK2A (p=0.929)
  • PRKCD (p=0.887)
  • CAMK1 (p=0.882)
  • MAPKAPK2 (p=0.879)
  • PRKAA1 (p=0.877)

Best loss of PTM site:

MAPK1 (probability p=0.955)
Site: 33S (phosphorylation)
Position in motif: 1
There are 9 other predicted losses:
  • MAPK3 (p=0.951)
  • MAPK14 (p=0.943)
  • CDK5 (p=0.935)
  • CDK1 (p=0.921)
  • MAPK11 (p=0.913)
  • CDK2 (p=0.908)
  • CDK6 (p=0.889)
  • CDK4 (p=0.884)
  • CDK7 (p=0.862)

Other known mutations affecting this site

Mutation In sequence Distance Impact
43F NVLSPLPSQAMDD[L/F]LM 6
distal
43M NVLSPLPSQAMDD[L/M]LM 6
distal
42G NVLSPLPSQAMD[D/G]DLM 5
distal
41G NVLSPLPSQAM[D/G]DDLM 4
distal
41N NVLSPLPSQAM[D/N]DDLM 4
distal
39V NVLSPLPSQ[A/V]AMDDLM 2
proximal
38P NVLSPLPS[Q/P]QAMDDLM 1
network-rewiring
37F NVLSPLP[S/F]SQAMDDLM 0
direct
36L NVLSPL[P/L]PSQAMDDLM 1
proximal
36Q NVLSPL[P/Q]PSQAMDDLM 1
proximal
35M NVLSP[L/M]LPSQAMDDLM 2
proximal
34L NVLS[P/L]PLPSQAMDDLM 3
network-rewiring
34R NVLS[P/R]PLPSQAMDDLM 3
network-rewiring
34S NVLS[P/S]PLPSQAMDDLM 3
distal
34A NVLS[P/A]PLPSQAMDDLM 3
distal
34T NVLS[P/T]PLPSQAMDDLM 3
distal
33F NVL[S/F]SPLPSQAMDDLM 4
distal
33Y NVL[S/Y]SPLPSQAMDDLM 4
distal
31F N[V/F]VLSPLPSQAMDDLM 6
distal
31I N[V/I]VLSPLPSQAMDDLM 6
distal

External references

dbSNP:
rs1322947350

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