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Mutation:
TP53 D57N
Summary
Isoform:
Position:
57
Ref:
D
Mutation:
N
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
MAPK group,
GRK5,
MAPK1,
TAF1
Clinical Information
Cancer types: (TCGA MC3)
LUAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 55T
Affected site:
Position: 55
Residue: T
Type: phosphorylation
Only loss of PTM site:
CAMK2A (probability p=0.857)
Site: 55T (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 54L | DDIEQW[F/L]FTEDPGPDE | 1 |
proximal
|
| 57E | DDIEQWFTE[D/E]DPGPDE | 2 |
proximal
|
| 57N | DDIEQWFTE[D/N]DPGPDE | 2 |
network-rewiring
|
| 58R | DDIEQWFTED[P/R]PGPDE | 3 |
distal
|
| 58T | DDIEQWFTED[P/T]PGPDE | 3 |
distal
|
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