You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TP53 D57E
Summary
Isoform:
Position:
57
Ref:
D
Mutation:
E
PTM impact:
proximal
PTM affected:
1
Kinases:
MAPK group,
GRK5,
MAPK1,
TAF1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 55T
Affected site:
Position: 55
Residue: T
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 61E | DDIEQWFTEDPGP[D/E]DE | 6 |
distal
|
| 61G | DDIEQWFTEDPGP[D/G]DE | 6 |
distal
|
| 60L | DDIEQWFTEDPG[P/L]PDE | 5 |
distal
|
| 59D | DDIEQWFTEDP[G/D]GPDE | 4 |
distal
|
| 58R | DDIEQWFTED[P/R]PGPDE | 3 |
distal
|
| 58T | DDIEQWFTED[P/T]PGPDE | 3 |
distal
|
| 57E | DDIEQWFTE[D/E]DPGPDE | 2 |
proximal
|
| 54L | DDIEQW[F/L]FTEDPGPDE | 1 |
proximal
|
| 52R | DDIE[Q/R]QWFTEDPGPDE | 3 |
network-rewiring
|
| 51G | DDI[E/G]EQWFTEDPGPDE | 4 |
distal
|
| 51K | DDI[E/K]EQWFTEDPGPDE | 4 |
distal
|
| 50T | DD[I/T]IEQWFTEDPGPDE | 5 |
distal
|
| 50N | DD[I/N]IEQWFTEDPGPDE | 5 |
distal
|
| 49G | D[D/G]DIEQWFTEDPGPDE | 6 |
distal
|
| 49H | D[D/H]DIEQWFTEDPGPDE | 6 |
distal
|
| 49N | D[D/N]DIEQWFTEDPGPDE | 6 |
distal
|
| 57N | DDIEQWFTE[D/N]DPGPDE | 2 |
network-rewiring
|
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us