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Mutation:
TP53 P58R
Summary
Isoform:
Position:
58
Ref:
P
Mutation:
R
PTM impact:
distal
PTM affected:
1
Kinases:
MAPK group,
TAF1,
GRK5,
MAPK1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
[0.0384]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 55T
Affected site:
Position: 55
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 61E | DDIEQWFTEDPGP[D/E]DE | 6 |
distal
|
| 61G | DDIEQWFTEDPGP[D/G]DE | 6 |
distal
|
| 60L | DDIEQWFTEDPG[P/L]PDE | 5 |
distal
|
| 59D | DDIEQWFTEDP[G/D]GPDE | 4 |
distal
|
| 58R | DDIEQWFTED[P/R]PGPDE | 3 |
distal
|
| 58T | DDIEQWFTED[P/T]PGPDE | 3 |
distal
|
| 57E | DDIEQWFTE[D/E]DPGPDE | 2 |
proximal
|
| 54L | DDIEQW[F/L]FTEDPGPDE | 1 |
proximal
|
| 52R | DDIE[Q/R]QWFTEDPGPDE | 3 |
network-rewiring
|
| 51G | DDI[E/G]EQWFTEDPGPDE | 4 |
distal
|
| 51K | DDI[E/K]EQWFTEDPGPDE | 4 |
distal
|
| 50T | DD[I/T]IEQWFTEDPGPDE | 5 |
distal
|
| 50N | DD[I/N]IEQWFTEDPGPDE | 5 |
distal
|
| 49G | D[D/G]DIEQWFTEDPGPDE | 6 |
distal
|
| 49H | D[D/H]DIEQWFTEDPGPDE | 6 |
distal
|
| 49N | D[D/N]DIEQWFTEDPGPDE | 6 |
distal
|
| 57N | DDIEQWFTE[D/N]DPGPDE | 2 |
network-rewiring
|
External references
dbSNP:
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