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Mutation:
TRA2B R117S
Summary
Isoform:
Position:
117
Ref:
R
Mutation:
S
PTM impact:
network-rewiring
PTM affected:
5
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
LUAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 110R
Affected site:
Position: 110
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 108I | TPGIY[M/I]MGRPTYGSSR | 2 |
proximal
|
PTM Site: 112T
Affected site:
Position: 112
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 108I | GIY[M/I]MGRPTYGSSRRR | 4 |
distal
|
| 117S | GIYMGRPTYGSS[R/S]RRR | 5 |
distal
|
| 117L | GIYMGRPTYGSS[R/L]RRR | 5 |
distal
|
PTM Site: 115S
Affected site:
Position: 115
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKCA (probability p=0.972)
Site: 115S (phosphorylation)
Position in motif: 2
There are 2 other predicted
losses:
- PRKCG (p=0.879)
- PRKCB (p=0.868)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 119L | MGRPTYGSSRR[R/L]RDYY | 4 |
distal
|
| 117S | MGRPTYGSS[R/S]RRRDYY | 2 |
network-rewiring
|
| 117L | MGRPTYGSS[R/L]RRRDYY | 2 |
network-rewiring
|
PTM Site: 116S
Affected site:
Position: 116
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 119L | GRPTYGSSRR[R/L]RDYYD | 3 |
distal
|
| 117S | GRPTYGSS[R/S]RRRDYYD | 1 |
proximal
|
| 117L | GRPTYGSS[R/L]RRRDYYD | 1 |
proximal
|
PTM Site: 124R
Affected site:
Position: 124
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 119L | RR[R/L]RDYYDRGYDRGYD | 5 |
distal
|
| 128W | RRRDYYDRGYD[R/W]RGYD | 4 |
distal
|
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