You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TRA2B P167T
Summary
Isoform:
Position:
167
Ref:
P
Mutation:
T
PTM impact:
network-rewiring
PTM affected:
7
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 160Y
Affected site:
Position: 160
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 158E | AQDRD[Q/E]QIYRRRSPSP | 2 |
proximal
|
| 156G | AQD[R/G]RDQIYRRRSPSP | 4 |
distal
|
PTM Site: 164S
Affected site:
Position: 164
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | DQIYRRRSPS[P/T]PYYSR | 3 |
distal
|
| 158E | D[Q/E]QIYRRRSPSPYYSR | 6 |
distal
|
| 167A | DQIYRRRSPS[P/A]PYYSR | 3 |
distal
|
| 168N | DQIYRRRSPSP[Y/N]YYSR | 4 |
distal
|
PTM Site: 166S
Affected site:
Position: 166
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.952)
Site: 166S (phosphorylation)
Position in motif: 1
There are 5 other predicted
losses:
- MAPK3 (p=0.942)
- MTOR (p=0.917)
- CDK6 (p=0.894)
- CDK5 (p=0.883)
- CDK2 (p=0.881)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | IYRRRSPS[P/T]PYYSRGG | 1 |
network-rewiring
|
| 171H | IYRRRSPSPYYS[R/H]RGG | 5 |
distal
|
| 167A | IYRRRSPS[P/A]PYYSRGG | 1 |
network-rewiring
|
| 168N | IYRRRSPSP[Y/N]YYSRGG | 2 |
proximal
|
PTM Site: 168Y
Affected site:
Position: 168
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | RRRSPS[P/T]PYYSRGGYR | 1 |
proximal
|
| 171H | RRRSPSPYYS[R/H]RGGYR | 3 |
distal
|
| 167A | RRRSPS[P/A]PYYSRGGYR | 1 |
proximal
|
| 168N | RRRSPSP[Y/N]YYSRGGYR | 0 |
direct
|
PTM Site: 169Y
Affected site:
Position: 169
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | RRSPS[P/T]PYYSRGGYRS | 2 |
proximal
|
| 171H | RRSPSPYYS[R/H]RGGYRS | 2 |
proximal
|
| 167A | RRSPS[P/A]PYYSRGGYRS | 2 |
proximal
|
| 168N | RRSPSP[Y/N]YYSRGGYRS | 1 |
proximal
|
PTM Site: 170S
Affected site:
Position: 170
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | RSPS[P/T]PYYSRGGYRSR | 3 |
distal
|
| 171H | RSPSPYYS[R/H]RGGYRSR | 1 |
proximal
|
| 167A | RSPS[P/A]PYYSRGGYRSR | 3 |
distal
|
| 168N | RSPSP[Y/N]YYSRGGYRSR | 2 |
proximal
|
PTM Site: 171R
Affected site:
Position: 171
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | SPS[P/T]PYYSRGGYRSRS | 4 |
distal
|
| 171H | SPSPYYS[R/H]RGGYRSRS | 0 |
direct
|
| 177L | SPSPYYSRGGYRS[R/L]RS | 6 |
distal
|
| 167A | SPS[P/A]PYYSRGGYRSRS | 4 |
distal
|
| 168N | SPSP[Y/N]YYSRGGYRSRS | 3 |
distal
|
If you have any questions or feedback about this mutation:
Contact us